Relict forms of copper-binding centers in human blood coagulation factor VIII

A number of mutations in the gene encoding human blood coagulation factor VIII (FVIII) may cause haemophilia A, which is a human X-chromosome-linked hereditary disease. Deciphering the structure and function of this protein remains a pressing research problem. The study revealed a conservative local...

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Bibliographic Details
Published in:Journal of evolutionary biochemistry and physiology 2015-03, Vol.51 (2), p.156-159
Main Authors: Moshkov, K. A., Maslov, V. G., Stefanov, V. E.
Format: Article
Language:English
Subjects:
Animal Physiology
Binding sites
Biochemistry
Biomedical and Life Sciences
Blood
Coagulation
Copper
Evolutionary Biology
Life Sciences
Short Communications
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Summary:A number of mutations in the gene encoding human blood coagulation factor VIII (FVIII) may cause haemophilia A, which is a human X-chromosome-linked hereditary disease. Deciphering the structure and function of this protein remains a pressing research problem. The study revealed a conservative localization of residues of the aforementioned centers and respective residues of the two copper-binding centers in ceruloplasmin (CP) domain, while in the study it was concluded that these centers in FVIII are prototypes of the copper-binding centers that contain nitrogen groups and sulfhydryl groups of amino acid residues.
ISSN:0022-0930
1608-3202
DOI:10.1134/S0022093015020106