Relict forms of copper-binding centers in human blood coagulation factor VIII

A number of mutations in the gene encoding human blood coagulation factor VIII (FVIII) may cause haemophilia A, which is a human X-chromosome-linked hereditary disease. Deciphering the structure and function of this protein remains a pressing research problem. The study revealed a conservative local...

Full description

Saved in:
Bibliographic Details
Published in:Journal of evolutionary biochemistry and physiology 2015-03, Vol.51 (2), p.156-159
Main Authors: Moshkov, K. A., Maslov, V. G., Stefanov, V. E.
Format: Article
Language:English
Subjects:
Animal Physiology
Binding sites
Biochemistry
Biomedical and Life Sciences
Blood
Coagulation
Copper
Evolutionary Biology
Life Sciences
Short Communications
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by
cites cdi_FETCH-LOGICAL-c268t-4856185c022ba9fc96857efaf69f8ab824b95d09277c61d9859f5e40e618aef63
container_end_page 159
container_issue 2
container_start_page 156
container_title Journal of evolutionary biochemistry and physiology
container_volume 51
creator Moshkov, K. A.
Maslov, V. G.
Stefanov, V. E.
description A number of mutations in the gene encoding human blood coagulation factor VIII (FVIII) may cause haemophilia A, which is a human X-chromosome-linked hereditary disease. Deciphering the structure and function of this protein remains a pressing research problem. The study revealed a conservative localization of residues of the aforementioned centers and respective residues of the two copper-binding centers in ceruloplasmin (CP) domain, while in the study it was concluded that these centers in FVIII are prototypes of the copper-binding centers that contain nitrogen groups and sulfhydryl groups of amino acid residues.
doi_str_mv 10.1134/S0022093015020106
format article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_1685139872</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3702634121</sourcerecordid><originalsourceid>FETCH-LOGICAL-c268t-4856185c022ba9fc96857efaf69f8ab824b95d09277c61d9859f5e40e618aef63</originalsourceid><addsrcrecordid>eNp1kE1LxDAQhoMouK7-AG8Bz9VJ2qTJURZ1CyuCX9eSpsnapZvUpD34781SD4J4msM8zzvDi9AlgWtC8uLmBYBSkDkQBhQI8CO0IBxEllOgx2hxWGeH_Sk6i3EHAFIUxQI9Ppu-0yO2Puwj9hZrPwwmZE3n2s5tsTZuNCHizuGPaa8cbnrv20Sp7dSrsfMOW6VHH_B7VVXn6MSqPpqLn7lEb_d3r6t1tnl6qFa3m0xTLsasEIwTwXT6qVHSaskFK41VlksrVCNo0UjWgqRlqTlppWDSMlOASZYyludLdDXnDsF_TiaO9c5PwaWTNUlZJJeipIkiM6WDjzEYWw-h26vwVROoD63Vf1pLDp2dmFi3NeFX8r_SNzckbPY</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1685139872</pqid></control><display><type>article</type><title>Relict forms of copper-binding centers in human blood coagulation factor VIII</title><source>Springer Link</source><creator>Moshkov, K. A. ; Maslov, V. G. ; Stefanov, V. E.</creator><creatorcontrib>Moshkov, K. A. ; Maslov, V. G. ; Stefanov, V. E.</creatorcontrib><description>A number of mutations in the gene encoding human blood coagulation factor VIII (FVIII) may cause haemophilia A, which is a human X-chromosome-linked hereditary disease. Deciphering the structure and function of this protein remains a pressing research problem. The study revealed a conservative localization of residues of the aforementioned centers and respective residues of the two copper-binding centers in ceruloplasmin (CP) domain, while in the study it was concluded that these centers in FVIII are prototypes of the copper-binding centers that contain nitrogen groups and sulfhydryl groups of amino acid residues.</description><identifier>ISSN: 0022-0930</identifier><identifier>EISSN: 1608-3202</identifier><identifier>DOI: 10.1134/S0022093015020106</identifier><language>eng</language><publisher>Moscow: Pleiades Publishing</publisher><subject>Animal Physiology ; Binding sites ; Biochemistry ; Biomedical and Life Sciences ; Blood ; Coagulation ; Copper ; Evolutionary Biology ; Life Sciences ; Short Communications</subject><ispartof>Journal of evolutionary biochemistry and physiology, 2015-03, Vol.51 (2), p.156-159</ispartof><rights>Pleiades Publishing, Ltd. 2015</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c268t-4856185c022ba9fc96857efaf69f8ab824b95d09277c61d9859f5e40e618aef63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Moshkov, K. A.</creatorcontrib><creatorcontrib>Maslov, V. G.</creatorcontrib><creatorcontrib>Stefanov, V. E.</creatorcontrib><title>Relict forms of copper-binding centers in human blood coagulation factor VIII</title><title>Journal of evolutionary biochemistry and physiology</title><addtitle>J Evol Biochem Phys</addtitle><description>A number of mutations in the gene encoding human blood coagulation factor VIII (FVIII) may cause haemophilia A, which is a human X-chromosome-linked hereditary disease. Deciphering the structure and function of this protein remains a pressing research problem. The study revealed a conservative localization of residues of the aforementioned centers and respective residues of the two copper-binding centers in ceruloplasmin (CP) domain, while in the study it was concluded that these centers in FVIII are prototypes of the copper-binding centers that contain nitrogen groups and sulfhydryl groups of amino acid residues.</description><subject>Animal Physiology</subject><subject>Binding sites</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Blood</subject><subject>Coagulation</subject><subject>Copper</subject><subject>Evolutionary Biology</subject><subject>Life Sciences</subject><subject>Short Communications</subject><issn>0022-0930</issn><issn>1608-3202</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><recordid>eNp1kE1LxDAQhoMouK7-AG8Bz9VJ2qTJURZ1CyuCX9eSpsnapZvUpD34781SD4J4msM8zzvDi9AlgWtC8uLmBYBSkDkQBhQI8CO0IBxEllOgx2hxWGeH_Sk6i3EHAFIUxQI9Ppu-0yO2Puwj9hZrPwwmZE3n2s5tsTZuNCHizuGPaa8cbnrv20Sp7dSrsfMOW6VHH_B7VVXn6MSqPpqLn7lEb_d3r6t1tnl6qFa3m0xTLsasEIwTwXT6qVHSaskFK41VlksrVCNo0UjWgqRlqTlppWDSMlOASZYyludLdDXnDsF_TiaO9c5PwaWTNUlZJJeipIkiM6WDjzEYWw-h26vwVROoD63Vf1pLDp2dmFi3NeFX8r_SNzckbPY</recordid><startdate>20150301</startdate><enddate>20150301</enddate><creator>Moshkov, K. A.</creator><creator>Maslov, V. G.</creator><creator>Stefanov, V. E.</creator><general>Pleiades Publishing</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QR</scope><scope>7SS</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88I</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M2P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope></search><sort><creationdate>20150301</creationdate><title>Relict forms of copper-binding centers in human blood coagulation factor VIII</title><author>Moshkov, K. A. ; Maslov, V. G. ; Stefanov, V. E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c268t-4856185c022ba9fc96857efaf69f8ab824b95d09277c61d9859f5e40e618aef63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Animal Physiology</topic><topic>Binding sites</topic><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Blood</topic><topic>Coagulation</topic><topic>Copper</topic><topic>Evolutionary Biology</topic><topic>Life Sciences</topic><topic>Short Communications</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Moshkov, K. A.</creatorcontrib><creatorcontrib>Maslov, V. G.</creatorcontrib><creatorcontrib>Stefanov, V. E.</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Neurosciences Abstracts</collection><collection>Health &amp; Medical Collection (ProQuest Medical &amp; Health Databases)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Biological Sciences</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>ProQuest Science Journals</collection><collection>ProQuest Biological Science Journals</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><jtitle>Journal of evolutionary biochemistry and physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Moshkov, K. A.</au><au>Maslov, V. G.</au><au>Stefanov, V. E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relict forms of copper-binding centers in human blood coagulation factor VIII</atitle><jtitle>Journal of evolutionary biochemistry and physiology</jtitle><stitle>J Evol Biochem Phys</stitle><date>2015-03-01</date><risdate>2015</risdate><volume>51</volume><issue>2</issue><spage>156</spage><epage>159</epage><pages>156-159</pages><issn>0022-0930</issn><eissn>1608-3202</eissn><abstract>A number of mutations in the gene encoding human blood coagulation factor VIII (FVIII) may cause haemophilia A, which is a human X-chromosome-linked hereditary disease. Deciphering the structure and function of this protein remains a pressing research problem. The study revealed a conservative localization of residues of the aforementioned centers and respective residues of the two copper-binding centers in ceruloplasmin (CP) domain, while in the study it was concluded that these centers in FVIII are prototypes of the copper-binding centers that contain nitrogen groups and sulfhydryl groups of amino acid residues.</abstract><cop>Moscow</cop><pub>Pleiades Publishing</pub><doi>10.1134/S0022093015020106</doi><tpages>4</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0022-0930
ispartof Journal of evolutionary biochemistry and physiology, 2015-03, Vol.51 (2), p.156-159
issn 0022-0930
1608-3202
language eng
recordid cdi_proquest_journals_1685139872
source Springer Link
subjects Animal Physiology
Binding sites
Biochemistry
Biomedical and Life Sciences
Blood
Coagulation
Copper
Evolutionary Biology
Life Sciences
Short Communications
title Relict forms of copper-binding centers in human blood coagulation factor VIII
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-02T16%3A27%3A06IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Relict%20forms%20of%20copper-binding%20centers%20in%20human%20blood%20coagulation%20factor%20VIII&rft.jtitle=Journal%20of%20evolutionary%20biochemistry%20and%20physiology&rft.au=Moshkov,%20K.%20A.&rft.date=2015-03-01&rft.volume=51&rft.issue=2&rft.spage=156&rft.epage=159&rft.pages=156-159&rft.issn=0022-0930&rft.eissn=1608-3202&rft_id=info:doi/10.1134/S0022093015020106&rft_dat=%3Cproquest_cross%3E3702634121%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c268t-4856185c022ba9fc96857efaf69f8ab824b95d09277c61d9859f5e40e618aef63%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1685139872&rft_id=info:pmid/&rfr_iscdi=true