Acute and late side effects to salivary glands and oral mucosa after head and neck radiotherapy in children and adolescents. Results of the "Registry for the evaluation of side effects after radiotherapy in childhood and adolescence"

Background The registry for the evaluation of side effects after radiotherapy in childhood and adolescence (RiSK) was established to prospectively characterize radiation‐associated side effects. The purpose of this analysis was to characterize side effects after radiotherapy to the head and neck in...

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Published in:Head & neck 2015-08, Vol.37 (8), p.1137-1141
Main Authors: Bölling, Tobias, Weege, Julia, Eich, Hans Theodor, Timmermann, Beate, Meyer, Frank-Michal, Rübe, Christian, Kortmann, Rolf-Dieter, Fischedick, Karin, Rödel, Claus, Koch, Raphael, Willich, Normann
Format: Article
Language:English
Subjects:
adolescence
Adolescent
Adult
Child
Child, Preschool
childhood
Dose-Response Relationship, Radiation
Female
Follow-Up Studies
Germany - epidemiology
head and neck
Head and Neck Neoplasms - radiotherapy
Humans
Infant
Male
Mouth Mucosa - radiation effects
Prospective Studies
radiation
Radiation Injuries - epidemiology
Radiation Injuries - etiology
Radiopharmaceuticals
Radiotherapy Dosage
Radiotherapy, Adjuvant - adverse effects
Registries
Risk Assessment
Risk Factors
salivary gland
Salivary Glands - radiation effects
Time Factors
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Summary:Background The registry for the evaluation of side effects after radiotherapy in childhood and adolescence (RiSK) was established to prospectively characterize radiation‐associated side effects. The purpose of this analysis was to characterize side effects after radiotherapy to the head and neck in children and adolescents. Methods Radiation doses have been collected across Germany since 2001. Acute and late side effects were characterized. Results Until January 2010, 133 patients (median age, 12.7 years) were recruited who had received radiotherapy to the salivary glands. Toxicity evaluation was available for 114 patients (median follow‐up, 2.9 years). Acute and late toxicity significantly depended on the maximum radiation dose to the salivary glands. An increase of the mean value of maximum dose of 1 Gray (Gy) to the submandibular glands resulted in an odds ratio of 1.04 (range, 1.00–1.08; p = .039) for acute toxicities of the salivary glands and 1.08 (range, 1.03–1.13; p = .001) for acute mucosal toxicities. Conclusion These data can be used for an individual risk assessment in pediatric head and neck radiotherapy. © 2014 Wiley Periodicals, Inc. Head Neck 37: 1137–1141, 2015
ISSN:1043-3074
1097-0347
DOI:10.1002/hed.23715