Chemoselective Pd-Catalyzed Isocyanide Insertion Reaction of Enaminones by C-H Functionalization: Hydrolysis or Cyclization through 1,3-Palladium Migration

A chemoselective palladium‐catalyzed isocyanide insertion reaction of enaminones was developed. Amide derivatives were synthesized by this C–H functionalization and subsequent hydrolysis reactions. 4‐Aminoquinoline derivatives were prepared by this C–H functionalization, which includes a 1,3‐palladi...

Full description

Saved in:
Bibliographic Details
Published in:European journal of organic chemistry 2015-07, Vol.2015 (21), p.4699-4709
Main Authors: Gu, Zheng-Yang, Wang, Xiang, Cao, Jia-Jia, Wang, Shun-Yi, Ji, Shun-Jun
Format: Article
Language:English
Subjects:
C-H activation
Chemoselectivity
Homogeneous catalysis
Insertion
Palladium
Synthetic methods
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A chemoselective palladium‐catalyzed isocyanide insertion reaction of enaminones was developed. Amide derivatives were synthesized by this C–H functionalization and subsequent hydrolysis reactions. 4‐Aminoquinoline derivatives were prepared by this C–H functionalization, which includes a 1,3‐palladium migration in the process. A chemoselective palladium‐catalyzed isocyanide insertion reaction of enaminones was developed. Amide derivatives were synthesized by this C–H functionalization and subsequent hydrolysis reactions, and 4‐aminoquinoline derivatives were prepared by this C–H functionalization, which includes a 1,3‐palladium migration in the process.
ISSN:1434-193X
1099-0690
DOI:10.1002/ejoc.201500458