Acid-Catalyzed Synthesis of [alpha]-Trifluoromethylthiolated Carbonyl Compounds

The [alpha]-trifluoromethylthiolation of carbonyl compounds in soft acidic conditions has been developed. With this method only mono-trifluoromethylthiolation was selectively observed. Base-sensitive ketones can then be trifluoromethylthiolated. More sensitive aldehydes are also trifluoromethylthiol...

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Published in:European journal of organic chemistry 2015-07, Vol.2015 (21), p.4607
Main Authors: Alazet, Sébastien, Ismalaj, Ermal, Glenadel, Quentin, Le Bars, Didier, Billard, Thierry
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Language:English
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Aldehydes
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container_issue 21
container_start_page 4607
container_title European journal of organic chemistry
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creator Alazet, Sébastien
Ismalaj, Ermal
Glenadel, Quentin
Le Bars, Didier
Billard, Thierry
description The [alpha]-trifluoromethylthiolation of carbonyl compounds in soft acidic conditions has been developed. With this method only mono-trifluoromethylthiolation was selectively observed. Base-sensitive ketones can then be trifluoromethylthiolated. More sensitive aldehydes are also trifluoromethylthiolated under these conditions with good yields. This work provides a new route towards the synthesis of various valuable trifluoromethylthiolated molecules.
doi_str_mv 10.1002/ejoc.201500710
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subjects Aldehydes
title Acid-Catalyzed Synthesis of [alpha]-Trifluoromethylthiolated Carbonyl Compounds
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