Synthesis of 1,2,4-Thiadiazoles by Oxidative Dimerization of Carbothioamides by Using Oxone

1,2,4‐Thiadiazoles were efficiently synthesized in good yields through the oxidative dimerization of carbothioamides by using Oxone as a readily available, inexpensive, and environmentally safe oxidant. A similar reaction of phenylselenoamide led to the corresponding 1,2,4‐phenylselenadiazole in hig...

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Bibliographic Details
Published in:European journal of organic chemistry 2014-08, Vol.2014 (24), p.5149-5152
Main Authors: Yoshimura, Akira, Todora, Anthony D., Kastern, Brent J., Koski, Steven R., Zhdankin, Viktor V.
Format: Article
Language:English
Subjects:
Heterocycles
Oxidation
Oxone
Selenium
Sulfur
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Summary:1,2,4‐Thiadiazoles were efficiently synthesized in good yields through the oxidative dimerization of carbothioamides by using Oxone as a readily available, inexpensive, and environmentally safe oxidant. A similar reaction of phenylselenoamide led to the corresponding 1,2,4‐phenylselenadiazole in high yield. 1,2,4‐Thiadiazoles are efficiently synthesized in good yields through the oxidative dimerization of carbothioamides by using Oxone as a readily available, inexpensive, and environmentally safe oxidant.
ISSN:1434-193X
1099-0690
DOI:10.1002/ejoc.201402756