A Common Precursor Approach to Structurally Diverse Natural Products: The Synthesis of the Core Structure of (±)-Clausenamide and the Total Synthesis of (±)-Hyalodendrin

Structurally diverse natural products from unrelated sources typically require the development of individual synthetic routes. In a novel approach, we have shown that the epidithiodiketopiperazine‐derived natural product (±)‐hyalodendrin and the core structure of the unrelated pyrrolidine‐derived na...

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Bibliographic Details
Published in:European journal of organic chemistry 2015-12, Vol.2015 (34), p.7438-7442
Main Authors: Szulc, Blanka R., Sil, Bruno C., Ruiz, Arnaud, Hilton, Stephen T.
Format: Article
Language:English
Subjects:
Clausenamide
Cyclization
Hyalodendrin
Natural products
Total synthesis
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Summary:Structurally diverse natural products from unrelated sources typically require the development of individual synthetic routes. In a novel approach, we have shown that the epidithiodiketopiperazine‐derived natural product (±)‐hyalodendrin and the core structure of the unrelated pyrrolidine‐derived natural product clausenamide can be synthesised from a common synthetic precursor in good yield by simple variation of the reaction conditions. Structurally unrelated natural products often require individual synthetic routes. In our approach, the epidithiodiketopiperazine natural product (±)‐hyalodendrin and the core structure of the unrelated pyrrolidine‐derived natural product clausenamide were synthesised from a common precursor by simple variation of the reaction conditions.
ISSN:1434-193X
1099-0690
DOI:10.1002/ejoc.201501256