Hepatitis E virus infection activates signal regulator protein [alpha] to down-regulate type I interferon

Hepatitis E virus (HEV) is a major cause of enterically transmitted acute hepatitis worldwide. However, the mechanism of HEV replication is unclear. Type I interferon is the first defense line of host against viral infection. Signal regulator protein [alpha] (SIRP-[alpha]) plays an important role in...

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Bibliographic Details
Published in:Immunologic research 2016-02, Vol.64 (1), p.115
Main Authors: Huang, Fen, Yang, Chenchen, Yu, Wenhai, Bi, Yanhong, Long, Feiyan, Wang, Jue, Li, Yunlong, Jing, Shenrong
Format: Article
Language:English
Subjects:
Hepatitis
Proteins
Studies
Viruses
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Summary:Hepatitis E virus (HEV) is a major cause of enterically transmitted acute hepatitis worldwide. However, the mechanism of HEV replication is unclear. Type I interferon is the first defense line of host against viral infection. Signal regulator protein [alpha] (SIRP-[alpha]) plays an important role in negative regulation of innate immunity. In the present study, HEV infection significantly activated the expression of SIRP-[alpha] and down-regulated phosphorylation of IRF3, consequently resulted in suppression of type I interferon (IFN-[beta]). In conclusion, HEV exploited SIRP-[alpha] to negative regulated IFN-[beta] of the host innate immune system to promote viral infection. It suggested that interfering with the functions of SIRP-[alpha] should be considered as a potential therapeutic approach to the prevention and treatment of HEV infection.
ISSN:0257-277X
1559-0755
DOI:10.1007/s12026-015-8729-y