Effects of Nicotine Patch vs Varenicline vs Combination Nicotine Replacement Therapy on Smoking Cessation at 26 Weeks: A Randomized Clinical Trial

IMPORTANCE: Smoking cessation medications are routinely used in health care; it is vital to identify medications that most effectively treat this leading cause of preventable mortality. OBJECTIVE: To compare the efficacies of varenicline, combination nicotine replacement therapy (C-NRT), and the nic...

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Bibliographic Details
Published in:JAMA : the journal of the American Medical Association 2016-01, Vol.315 (4), p.371-379
Main Authors: Baker, Timothy B, Piper, Megan E, Stein, James H, Smith, Stevens S, Bolt, Daniel M, Fraser, David L, Fiore, Michael C
Format: Article
Language:English
Subjects:
Adult
Carbon Monoxide - blood
Clinical trials
Counseling
Female
Humans
Intention to Treat Analysis
Male
Medication Adherence
Middle Aged
Nicotine - administration & dosage
Nicotine - adverse effects
Nicotinic Agonists - administration & dosage
Nicotinic Agonists - adverse effects
Outcome Assessment (Health Care)
Patient safety
Smoking - adverse effects
Smoking - blood
Smoking - drug therapy
Smoking cessation
Smoking Cessation - methods
Substance Withdrawal Syndrome - therapy
Time Factors
Tobacco Use Cessation Products - adverse effects
Transdermal medication
Varenicline - administration & dosage
Varenicline - adverse effects
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