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Ponatinib in chronic myeloid leukaemia and Philadelphia chromosome-positive acute lymphoblastic leukaemia: a guide to its use in the EU
Oral ponatinib (Iclusig ® ) is a novel kinase inhibitor that was designed to overcome resistance mutations in the ABL kinase domain, including T315I. In a phase 2 study, ponatinib therapy was associated with a major cytogenetic response within the first 12 months in >50 % of adults with chronic-p...
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Published in: | Drugs & therapy perspectives : for rational drug selection and use 2016, Vol.32 (1), p.13-17 |
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Main Authors: | , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites |
Online Access: | Get full text |
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Summary: | Oral ponatinib (Iclusig
®
) is a novel kinase inhibitor that was designed to overcome resistance mutations in the
ABL
kinase domain, including T315I. In a phase 2 study, ponatinib therapy was associated with a major cytogenetic response within the first 12 months in >50 % of adults with chronic-phase chronic myeloid leukaemia (CML) and major haematological responses within the first 6 months in ≥50 % of adults with accelerated-phase CML and ≈34 % of adults with blast-phase CML or Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukaemia (ALL); responses were seen regardless of whether patients were resistant or intolerant to prior dasatinib or nilotinib, or had the T315I mutation. Ponatinib had a manageable tolerability profile; vascular occlusions, cardiac failure and pancreatitis have been reported with ponatinib. Ponatinib is a useful option for adults with chronic-, accelerated- or blast-phase CML or Ph+ ALL who are resistant or intolerant to prior tyrosine kinase inhibitor therapy or who have the T315I mutation. |
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ISSN: | 1172-0360 1179-1977 |
DOI: | 10.1007/s40267-015-0265-2 |