Synthesis and Bioactivities of Andrographolide Derivatives： New （-）-Limonidilactone Analogues

In this study, a novel route to （-）-limonidilactone analogues 10, 11 by way of stereoselective reaction of andrographolide （5） from 8, 9 was reported. The anti-tumor and a-glucosidsae inhibition activities of some synthetic compounds were screened.

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Published in:Chinese journal of chemistry 2011-10, Vol.29 (10), p.2114-2118
Main Author: 徐海伟 姜平娟 李伟义 王俊峰 刘宏民
Format: Article
Language:English
Subjects:
andrographolide
bioactivity
limonidilactone
oxo-michael addition reaction
synthesis
人工合成
化合物
抗肿瘤
生物活性
穿心莲内酯
立体选择性反应
类似物
衍生物
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cited_by cdi_FETCH-LOGICAL-c3816-efd474261478c31bb677e25f3a3dd2264bd9d2889e5bd46af69f45beeab783633
cites cdi_FETCH-LOGICAL-c3816-efd474261478c31bb677e25f3a3dd2264bd9d2889e5bd46af69f45beeab783633
container_end_page 2118
container_issue 10
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container_title Chinese journal of chemistry
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creator 徐海伟 姜平娟 李伟义 王俊峰 刘宏民
description In this study, a novel route to （-）-limonidilactone analogues 10, 11 by way of stereoselective reaction of andrographolide （5） from 8, 9 was reported. The anti-tumor and a-glucosidsae inhibition activities of some synthetic compounds were screened.
doi_str_mv 10.1002/cjoc.201180366
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subjects andrographolide
bioactivity
limonidilactone
oxo-michael addition reaction
synthesis
人工合成
化合物
抗肿瘤
生物活性
穿心莲内酯
立体选择性反应
类似物
衍生物
title Synthesis and Bioactivities of Andrographolide Derivatives： New （-）-Limonidilactone Analogues
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