Maternal factors in the origin of infantile hypertrophic pyloric stenosis: A population-based case-control study

In most patients affected by isolated infantile hypertrophic pyloric stenosis (IHPS) the etiology is largely unknown. Thus, the aim of this study was to estimate possible maternal risk factors in the origin of IHPS. The study samples included 241 cases with IHPS, 357 matched controls and 38 151 popu...

Full description

Saved in:
Bibliographic Details
Published in:Congenital anomalies 2016-03, Vol.56 (2), p.65-72
Main Authors: Vermes, Gabor, László, Daniel, Czeizel†, Andrew E., Ács, Nándor
Format: Article
Language:English
Subjects:
Case-Control Studies
Female
Hemorrhage
Humans
Hungary - epidemiology
Hyperthyroidism
infantile hypertrophc pyloric stenosis
Male
Maternal Exposure - adverse effects
nalidixic acid
population based case-control study
Population Surveillance
Pregnancy
Pregnancy Complications
Prevalence
Pyloric Stenosis, Hypertrophic - epidemiology
Pyloric Stenosis, Hypertrophic - etiology
Registries
Retina
Risk Factors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In most patients affected by isolated infantile hypertrophic pyloric stenosis (IHPS) the etiology is largely unknown. Thus, the aim of this study was to estimate possible maternal risk factors in the origin of IHPS. The study samples included 241 cases with IHPS, 357 matched controls and 38 151 population controls without any defect in the population‐based large dataset of the Hungarian Case‐Control Surveillance of Congenital Abnormalities, 1980–1996. Exposures that had been medically recorded in prenatal maternity logbooks during the critical period of IHPS were evaluated separately. The findings of this case‐control study suggested that – beyond the well‐known robust male excess (85.5%) – maternal hyperthyroidism (OR with 95% CI: 4.17, 1.53–11.38) and oral nalidixic acid treatment (OR with 95% CI: 6.53, 3.03–14.06) associated with a higher risk for IHPS in their children. In conclusion, our findings suggest that cases with IHPS had mothers with a higher proportion of hyperthyroidism and nalidixic acid treatment during pregnancy.
ISSN:0914-3505
1741-4520
DOI:10.1111/cga.12134