SCS macrophages suppress melanoma by restricting tumor-derived vesicle–B cell interactions

Tumor-derived extracellular vesicles (tEVs) are important signals in tumor–host cell communication, yet it remains unclear how endogenously produced tEVs affect the host in different areas of the body. We combined imaging and genetic analysis to track melanoma-derived vesicles at organismal, cellula...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 2016-04, Vol.352 (6282), p.242-246
Main Authors: Pucci, Ferdinando, Garris, Christopher, Lai, Charles P., Newton, Andita, Pfirschke, Christina, Engblom, Camilla, Alvarez, David, Sprachman, Melissa, Evavold, Charles, Magnuson, Angela, von Andrian, Ulrich H., Glatz, Katharina, Breakefield, Xandra O., Mempel, Thorsten R., Weissleder, Ralph, Pittet, Mikael J.
Format: Article
Language:English
Subjects:
Animals
B-Lymphocytes - immunology
B-Lymphocytes - ultrastructure
Cancer
Cell Communication
Extracellular Vesicles - immunology
Humans
Immune system
Immune Tolerance
Lymph nodes
Lymph Nodes - immunology
Lymphatic Vessels - immunology
Macrophages - chemistry
Macrophages - immunology
Melanoma
Melanoma - immunology
Melanoma - pathology
Melanoma, Experimental - immunology
Melanoma, Experimental - pathology
Mice
Mice, Inbred C57BL
Rodents
Sialic Acid Binding Ig-like Lectin 1 - analysis
Sialic Acid Binding Ig-like Lectin 1 - immunology
Skin Neoplasms - immunology
Skin Neoplasms - pathology
Tissues
Tumors
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