Iodine-Catalyzed Oxidative Benzylic C−H Bond Amination of Azaarenes: Practical Synthesis of Quinazolin-4(3 H)-ones

An efficient iodine‐catalyzed oxidative benzylic C−H bond amination of azaarenes to afford 2‐heteroaryl quinazolinones has been developed. This reaction utilizes unfunctionalized alkyl azaarenes as starting materials and proceeds under metal‐free conditions with dioxygen as the terminal oxidant, thu...

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Bibliographic Details
Published in:Asian journal of organic chemistry 2016-04, Vol.5 (4), p.494-498
Main Authors: Yang, Luo, Shi, Xin, Hu, Ben-Quan, Wang, Li-Xia
Format: Article
Language:English
Subjects:
amination
azaarenes
C−H bond transformation
Iodine
Organic chemistry
quinazolin-4(3 H)-ones
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Summary:An efficient iodine‐catalyzed oxidative benzylic C−H bond amination of azaarenes to afford 2‐heteroaryl quinazolinones has been developed. This reaction utilizes unfunctionalized alkyl azaarenes as starting materials and proceeds under metal‐free conditions with dioxygen as the terminal oxidant, thus is much “greener” than the previous synthetic methods. Az you like it: An efficient, iodine‐catalyzed, oxidative, benzylic C−H bond amination of azaarenes to afford 2‐heteroaryl quinazolinones has been developed.
ISSN:2193-5807
2193-5815
DOI:10.1002/ajoc.201600041