Psychiatric and Behavioural Disorders in Children with Epilepsy (ILAE Task Force Report): Adverse cognitive and behavioural effects of antiepileptic drugs in children

ABSTRACT The literature was evaluated for cognitive and more general behavioural effects. We distinguished the older antiepileptic drugs (AEDs), from the newer and newest AEDs. The striking finding was the lack of information on children. From the available evidence it would appear that there may be...

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Bibliographic Details
Published in:Epileptic disorders 2016-05, Vol.18 (s1), p.S55-S67
Main Authors: Aldenkamp, Albert, Besag, Frank, Gobbi, Giuseppe, Caplan, Rochelle, Dunn, David W., Sillanpää, Matti
Format: Article
Language:English
Subjects:
antiepileptic drug
attention
cognition
Convulsions & seizures
memory
Prescription drugs
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Summary:ABSTRACT The literature was evaluated for cognitive and more general behavioural effects. We distinguished the older antiepileptic drugs (AEDs), from the newer and newest AEDs. The striking finding was the lack of information on children. From the available evidence it would appear that there may be negative cognitive effects with phenobarbital, phenytoin, topiramate and zonisamide, and adverse behavioural effects with phenobarbital, valproate, gabapentin, topiramate, levetiracetam and zonisamide. There is inconclusive data on ethosuximide, clobazam, vigabatrin, felbamate, pregabalin, stiripentol, rufinamide, lacosamide and retigabine. The following drugs appear to be neutral with regard to cognitive effects: valproate, carbamazepine, gabapentin and oxcarbazepine. Carbamazepine appears to be neutral with regard to behavioural effects. Positive cognitive effects have been reported with lamotrigine and levetiracetam. Positive behavioural effects have been reported with lamotrigine. Recommendations are provided.
ISSN:1294-9361
1950-6945
DOI:10.1684/epd.2016.0817