Reg4⁺ deep crypt secretory cells function as epithelial niche for Lgr5⁺ stem cells in colon

Leucine-rich repeat-containing G-protein coupled receptor 5-positive (Lgr5⁺) stem cells reside at crypt bottoms of the small and large intestine. Small intestinal Paneth cells supply Wnt3, EGF, and Notch signals to neighboring Lgr5⁺ stem cells. Whereas the colon lacks Paneth cells, deep crypt secret...

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Published in:	Proceedings of the National Academy of Sciences - PNAS 2016-09, Vol.113 (37), p.E5399-E5407
Main Authors:	Sasaki, Nobuo, Sachs, Norman, Wiebrands, Kay, Ellenbroek, Saskia I. J., Fumagalli, Arianna, Lyubimova, Anna, Begthel, Harry, van den Born, Maaike, van Es, Johan H., Karthaus, Wouter R., Li, Vivian S. W., López-Iglesias, Carmen, Peters, Peter J., van Rheenen, Jacco, van Oudenaarden, Alexander, Clevers, Hans
Format:	Article
Language:	English
Subjects:	Amino acids Animals Biological Sciences Cell Biology Colon - cytology Colon - growth & development Colon - metabolism Colonic Neoplasms - metabolism Colonic Neoplasms - pathology Digestive system Epithelial Cells - metabolism Epithelial Cells - pathology Homeostasis Intestine, Small - cytology Intestine, Small - metabolism Mice Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Organoids - growth & development Organoids - metabolism Pancreatitis-Associated Proteins Paneth Cells - cytology Paneth Cells - metabolism PNAS Plus Proteins Receptors, G-Protein-Coupled - genetics Receptors, G-Protein-Coupled - metabolism Receptors, Notch - genetics Stem Cell Niche - genetics Stem cells Stem Cells - cytology Stem Cells - metabolism Toxins Wnt Signaling Pathway - genetics
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