New Iridoid Glucosides from Caryopteris incana (Thunb.) Miq. and Their [alpha]-Glucosidase Inhibitory Activities

In our continued investigations of the plant Caryopteris incana, five new iridoid glucosides 1-5, including two cis-trans-isomers, 3 and 4, along with six known compounds 6-11, were isolated from the n-butyl alcohol (n-BuOH) soluble fraction of whole dried material of Caryopteris incana. Their struc...

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Published in:Molecules (Basel, Switzerland) Switzerland), 2016-12, Vol.21 (12), p.1749
Main Authors: Mao, Xu-Dong, Chou, Gui-Xin, Zhao, Sen-Miao, Zhang, Cheng-Gang
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Language:English
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Alcohol
Diabetes
Spectrum analysis
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description In our continued investigations of the plant Caryopteris incana, five new iridoid glucosides 1-5, including two cis-trans-isomers, 3 and 4, along with six known compounds 6-11, were isolated from the n-butyl alcohol (n-BuOH) soluble fraction of whole dried material of Caryopteris incana. Their structures were established by a combination of spectroscopic techniques, including 1D and 2D NMR and high resolution electrospray ionization mass spectroscopy (HR-ESI-MS). Furthermore, all isolates were evaluated for their yeast [alpha]-glucosidase inhibitory effects. Among these compounds, 4-8 and 10 exhibited potent inhibition of [alpha]-glucosidase.
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subjects Alcohol
Diabetes
Spectrum analysis
title New Iridoid Glucosides from Caryopteris incana (Thunb.) Miq. and Their [alpha]-Glucosidase Inhibitory Activities
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