Does Intramuscular Injection into Paralyzed Tissue in Rats Alter the Absorption of Drugs? An Experimental Multidisciplinary Study

This study examined if there was altered absorption of a drug administered by intramuscular injection into paralyzed tissue in rats with sciatic nerve injury. In this experimental study 16 female Spraque Dawley rats (250-300 gr) and diclofenac sodium as drug were used. The rats were randomly divided...

Full description

Saved in:
Bibliographic Details
Published in:International journal of caring sciences 2016-09, Vol.9 (3), p.1083
Main Authors: Coban, Gulay Ipek, Akpinar, Reva Balci, Coban, Mustafa Kemal, Akpinar, Erol, Atilla, Alptug, Kadioglu, Yucel, Yaman, Mehmet Emrah
Format: Article
Language:English
Subjects:
Bioavailability
Chromatography
College professors
Drugs
Injuries
Laboratories
Metabolism
Nurses
Paralysis
Rodents
Spinal cord
Studies
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:This study examined if there was altered absorption of a drug administered by intramuscular injection into paralyzed tissue in rats with sciatic nerve injury. In this experimental study 16 female Spraque Dawley rats (250-300 gr) and diclofenac sodium as drug were used. The rats were randomly divided into two groups. Axonotmesis was caused by clamping the rats' sciatic nerves. Seven days after sciatic nerve trauma, drug were injected into the biceps femoris muscles of the two groups of rats. In the experimental groups of rats the paralyzed muscles were used. At the end of the experiment, blood samples were collected from the rats' heart and the maximum plasma concentration levels of drug were measured. The mean drug plasma concentrations levels of the experimental group was 8.84 ^g/ml and the control group was 9.46 ^g/ml. There was no significant difference between experimental group and control group terms of drug levels in plasma. Intramuscular injection into paralyzed tissue in rats does not alter the absorption of a drug.
ISSN:1791-5201
1792-037X