G268 Prenatal and perinatal risk factors for childhood disability in a rural Nepali birth cohort

• Published in: Archives of disease in childhood 2016-04, Vol.101 (Suppl 1), p.A149-A152
• Main Authors: Haworth, E, Tumbahangphe, KM, Costello, A, Manandhar, D, Adhikari, D, Budhathoki, B, Shrestha, DK, Sagar, K, Heys, M
• Format: Article
• Language: English
• Subjects: Attrition (Research Studies); Cohabitation; Low income areas; Malnutrition; Neonates; Poverty; Pregnancy; Risk factors; Socioeconomics
• ISSN: 0003-9888; 1468-2044
• DOI: 10.1136/archdischild-2016-310863.260

AimThere has been a renewed focus globally on neonatal mortality as the deadline for the Millennium Development Goals approaches.1 Little is known about the neurodevelopmental consequences for survivors of complications in pregnancy, labour and the neonatal period in in low income countries outside of small, selective and typically urban facility studies.2 We ask which antenatal, birth and neonatal factors are associated with disability at age eleven in a large community recruited birth cohort from rural Nepal.MethodsThis cohort of 6,285 live births was recruited during a cluster randomised control trial of participatory women’s group on neonatal mortality.3,4 At age eleven 4,219 children were available for detailed follow up assessment including disability screening, with a retention rate in survivors of 72% (Figure 1). Disability was assessed by face to face interview using the newly developed UN/UNICEF Module on Child Functioning and Disability.5 Abstract G268 Figure 1Flowchart of rectuitsTo minimise the risk of posthoc testing first a list of hypothesised risk factors for adverse outcome was drawn up which was then consummated with the available data (Table 1). Factors with a univariate significance of