Synthesis and self-assembly behavior of novel polyaspartamide derivatives for anti-tumor drug delivery

A series of amphiphilic graft copolymers based on polyaspartamide were synthesized by a successive aminolysis reaction of polysuccinimide using 2-diisopropylaminoethyl (DIP) and laurylamine as a pH sensitive and hydrophobic group, respectively. The pH-dependent self-assembly behavior of the aqueous...

Full description

Saved in:
Bibliographic Details
Published in:Colloid and polymer science 2011, Vol.289 (1), p.63-71
Main Authors: Moon, Jong Rok, Kim, Min Woong, Kim, Dukjoon, Jeong, Ji Hoon, Kim, Ji-Heung
Format: Article
Language:English
Subjects:
Aminoacid polymers
Amphiphilic
Applied sciences
Biological and medical sciences
Characterization and Evaluation of Materials
Chemistry
Chemistry and Materials Science
Complex Fluids and Microfluidics
Exact sciences and technology
Food Science
General pharmacology
Graft copolymer
Medical sciences
nanoparticles
Nanotechnology and Microengineering
Original Contribution
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Physical Chemistry
Physicochemistry of polymers
Polymer Sciences
Soft and Granular Matter
Stimuli-responsive
Synthetic biopolymers
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A series of amphiphilic graft copolymers based on polyaspartamide were synthesized by a successive aminolysis reaction of polysuccinimide using 2-diisopropylaminoethyl (DIP) and laurylamine as a pH sensitive and hydrophobic group, respectively. The pH-dependent self-assembly behavior of the aqueous copolymer solution was investigated. Nano-aggregation occurred at a pH in the vicinity of the pKa of the DIP group, which was induced by a hydrophilic-hydrophobic shift of the DIP group in solution. The mean diameter of the nano-aggregate could be modulated by changing the composition of both pendants. The mean diameter of the nanoparticles increased with increasing solution pH from 6.5 to 8. At pH 8, the mean diameter of the nanoparticles increased rapidly at the temperature above 45 °C, probably due to the change in hydrophilic-hydrophobic balance of the pH-sensitive DIP moiety. The dissolution of paclitaxel (PTX) into this amphiphilic nanoparticle was attempted and the pH-dependent release behavior was examined with the stability study of the particle. The results showed significantly faster release of PTX at pH 6.5, which is a tumoral acidic pH, than in a neutral physiological pH. These thermo- and pH-sensitive polyaspartamide derivatives have potential use as a tumor-targeting delivery.
ISSN:0303-402X
1435-1536
DOI:10.1007/s00396-010-2307-6