Synthesis and Fungicidal Activity of Novel 2‐Heteroatomthiazole‐based Carboxanilides

A new series of 2‐heteroatomthiazole‐based carboxanilides (8) are prepared by reacting 2‐heteroatomthiazole‐based carboxylic acid chlorides with 2,6‐dibromo‐4‐(trifluoromethoxy)aniline. The structures of all the newly synthesized compounds were supported by spectroscopic data NMR, MS, and elemental...

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Published in:Journal of heterocyclic chemistry 2017-03, Vol.54 (2), p.1625-1629
Main Authors: Liu, Aiping, Wang, Xiaoguang, Liu, Xingping, Li, Jianming, Chen, Haobin, Hu, Li, Yu, Wanqi, He, Lian, Liu, Weidong, Huang, Mingzhi
Format: Article
Language:English
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Summary:A new series of 2‐heteroatomthiazole‐based carboxanilides (8) are prepared by reacting 2‐heteroatomthiazole‐based carboxylic acid chlorides with 2,6‐dibromo‐4‐(trifluoromethoxy)aniline. The structures of all the newly synthesized compounds were supported by spectroscopic data NMR, MS, and elemental analysis, etc. Bioassay showed that the compounds exhibited potent fungicidal activities against Rhizoctonia solani, etc. Particularly, N‐(2,6‐dibromo‐4‐(trifluoromethoxy)phenyl)‐2‐methoxy‐4‐(trifluoromethyl)thiazole‐5‐carboxamide (8a-2) showed fungicidal potency which was comparable to that of Thifluzamide, the only commercialized thiazole carboxanilide fungicides of succinate dehydrogenase inhibitor (SDHI).
ISSN:0022-152X
1943-5193
DOI:10.1002/jhet.2668