Optical diagnosis of dengue virus infected human blood using Mueller matrix polarimetry

Currently dengue fever diagnosis methods include capture ELISAs, immunofluorescence tests, and hemagglutination assays. In this study optical diagnosis of dengue virus infection in the whole blood is presented utilizing Mueller matrix polarimetry. Mueller matrices of about 50 dengue viral infected a...

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Bibliographic Details
Published in:Optics and spectroscopy 2016-08, Vol.121 (2), p.322-325
Main Authors: Anwar, Shahzad, Firdous, Shamaraz
Format: Article
Language:English
Subjects:
Blood
Dengue fever
Depolarization
Diagnosis
Fever
Geometrical and Applied Optics
Immunofluorescence
Infections
Lasers
Optical activity
Optical Devices
Optical properties
Optics
Photonics
Physics
Physics and Astronomy
Polarimetry
Polarization
Polarized light
Viral diseases
Viral infections
Viruses
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Summary:Currently dengue fever diagnosis methods include capture ELISAs, immunofluorescence tests, and hemagglutination assays. In this study optical diagnosis of dengue virus infection in the whole blood is presented utilizing Mueller matrix polarimetry. Mueller matrices of about 50 dengue viral infected and 25 non-dengue healthy blood samples were recorded utilizing light source from 500 to 700 nm with scanning step of 10 nm. Polar decomposition of the Mueller matrices for all the blood samples was performed that yielded polarization properties including depolarization, diattenuation, degree of polarization, retardance and optical activity, out of which, depolarization index clusters up the diseased and healthy in to different separate groups. The average depolarized light in the case of dengue infection in the whole blood at 500 nm is 18%, whereas for the healthy blood samples it is 13.5%. This suggests that depolarization index of polarized light at the wavelengths of 500, 510, 520, 530 and 540 nm, we find that in case of depolarization index values are higher for dengue viral infection as compared to normal samples. This technique can effectively be used for the characterization of the dengue virus infected at an early stage of disease.
ISSN:0030-400X
1562-6911
DOI:10.1134/S0030400X16080208