Early peripheral sensory neurons in the development of trochozoan animals

Neuronal development of the majority of trochozoan animals with biphasic pelago-bentic life cycle starts from transient peripheral neurons, which do not belong to the central nervous system and are mainly located in the apical sensory organ and in the hyposphere. Some of these neurons are pioneer an...

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Bibliographic Details
Published in:Russian journal of developmental biology 2017-03, Vol.48 (2), p.130-143
Main Authors: Nezlin, L. P., Voronezhskaya, E. E.
Format: Article
Language:English
Subjects:
Animal Anatomy
Antibodies
Axons
Biomedical and Life Sciences
Central nervous system
Chemoreception
Cilia
Developmental Biology
FMRFamide
Histology
Larvae
Life cycles
Life Sciences
Morphogenesis
Morphology
Nervous system
Neurons
Neurotransmitters
Sensory neurons
Serotonin
Tubulin
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Summary:Neuronal development of the majority of trochozoan animals with biphasic pelago-bentic life cycle starts from transient peripheral neurons, which do not belong to the central nervous system and are mainly located in the apical sensory organ and in the hyposphere. Some of these neurons are pioneer and send neurites that form a scaffold upon which the adult central nervous system later develops. In representative species of molluscs and polychaetes, immunolabelling with the antibodies against neurotransmitters serotonin and FMRFamide, and acetylated α-tubulin revealed that the structure of almost all early peripheral neurons is typical for sensory, most probably chemosensory cells: flask shape, and cilia at the end of the apical dendrite or inside the distal ampoule. Morphology, transmitter specificity, location and projections of the early sensory cells differ in trochophores of different species thus suggesting different origin of these cells. In polychaete larvae, pharmacological inhibition of serotonin synthesis in early peripheral neurons did not affect the development, whereas its increase resulted in developmental arrest and neural malformations, suggesting that early peripheral sensory neurons are involved in developmental regulation.
ISSN:1062-3604
1608-3326
DOI:10.1134/S1062360417020060