Anthropometric measurements of the body composition of cancer patients determine the precise role of the body surface area and the calculation of the dose of chemotherapy

The calculation of an accurate dose of chemotherapy for oncological patients reduces the possible medication errors and the toxicity of the body and so it improves the outcome of the treatment (survival). In oncological practice for the calculation of the dose of chemotherapy the human body surface...

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Bibliographic Details
Published in:Papers on anthropology 2012-01, Vol.21 (21), p.56
Main Authors: Gerina-Berzina, Aija, Vikmanis, Uldis, Teibe, Uldis, Umbrashko, Silvija
Format: Article
Language:English
Subjects:
Anthropometry
Arithmetic
Averages
Body composition
Body fat
Body mass index
Body weight
Cancer
Cancer patients
Chemotherapy
Computation
Correlation analysis
Critical incidents
Density
Dosage
Drugs
Fat content
Females
Gender differences
Measurement
Medication errors
Obesity
Pharmacokinetics
Physiological aspects
Tomography
Tumors
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Summary:The calculation of an accurate dose of chemotherapy for oncological patients reduces the possible medication errors and the toxicity of the body and so it improves the outcome of the treatment (survival). In oncological practice for the calculation of the dose of chemotherapy the human body surface area (BSA) is used. The human body surface area is determined by derived formulas, but it is not directly linked to the pharmacokinetics of the drugs. Pharmacokinetic studies have demonstrated that for the calculation of the chemotherapy dose the actual body weight should be taken into account rather than the ideal one. In the therapeutic dose determination the body fat mass has essential significance. 202 patients aged from 19 to 83 years with various tumor localizations underwent anthropometric measurements (height, weight, circumferences, fatfold thickness, the distance between the hills above the joint), the body mass index (BMI) and the BSA (according to the Mosteller formula). The average weight of 99 men was 78.5 ± 16.4 kg and the mean body weight of 103 women was 70.1 ± 14.6 kg, statistically non-significantly different (F = 0.358, p = 0.551), but the independent-sample t-test arithmetical mean differed statistically significantly (t = 3.839, p
ISSN:1406-0140
1736-7646
DOI:10.12697/poa.2012.21.05