Synthesis and biological evaluation of oxadiazole incorporated ellipticine derivatives as anticancer agents

A series of oxadiazole incorporated ellipticine derivatives were synthesized and evaluated for their anticancer activity on human cancer cell lines Colo-205, MCF-7, A-549, and KB. Five of the newly synthesized target products exhibited potent cytotoxic activities with GI 50 values ranging from

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Bibliographic Details
Published in:Monatshefte für Chemie 2017-05, Vol.148 (5), p.933-938
Main Authors: Madhavi, Sapavat, Sreenivasulu, Reddymasu, Raju, Rudraraju Ramesh
Format: Article
Language:English
Subjects:
Analytical Chemistry
Anticancer properties
Cancer
Chemical synthesis
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Inorganic Chemistry
Organic Chemistry
Original Paper
Oxadiazoles
Physical Chemistry
Theoretical and Computational Chemistry
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Description
Summary:A series of oxadiazole incorporated ellipticine derivatives were synthesized and evaluated for their anticancer activity on human cancer cell lines Colo-205, MCF-7, A-549, and KB. Five of the newly synthesized target products exhibited potent cytotoxic activities with GI 50 values ranging from
ISSN:0026-9247
1434-4475
DOI:10.1007/s00706-016-1790-y