Activity‐based probes for the ubiquitin conjugation–deconjugation machinery: new chemistries, new tools, and new insights

The reversible post‐translational modification of proteins by ubiquitin and ubiquitin‐like proteins regulates almost all cellular processes, by affecting protein degradation, localization, and complex formation. Deubiquitinases (DUBs) are proteases that remove ubiquitin modifications or cleave ubiqu...

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Bibliographic Details
Published in:The FEBS journal 2017-05, Vol.284 (10), p.1555-1576
Main Authors: Hewings, David S., Flygare, John A., Bogyo, Matthew, Wertz, Ingrid E.
Format: Article
Language:English
Subjects:
active sites
activity‐based probe
activity‐based protein profiling
Animals
Biodegradation
Chemical activity
chemical bonding
chemoproteomics
Complex formation
Conjugation
Cysteine
cysteine proteinases
deubiquitinase
Deubiquitinating Enzymes - metabolism
enzyme activity
enzyme inhibitors
Enzymes
Humans
Localization
Peptide Hydrolases - metabolism
Post-translation
post-translational modification
Probes
protease
Proteases
Proteasome Endopeptidase Complex - metabolism
protein degradation
Protein Processing, Post-Translational
Proteins
Proteolysis
Review
Special Issue: Proteases
Ubiquitin
Ubiquitin - metabolism
Ubiquitin-protein ligase
Ubiquitin-Specific Proteases - metabolism
ubiquitin–proteasome system
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