Tailored Polarizing Hybrid Solids with Nitroxide Radicals Localized in Mesostructured Silica Walls

Hyperpolarization by dynamic nuclear polarization relies on the microwave irradiation of paramagnetic radicals dispersed in molecular glasses to enhance the nuclear magnetic resonance (NMR) signals of target molecules. However, magnetic or chemical interactions between the radicals and the target mo...

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Bibliographic Details
Published in:Helvetica chimica acta 2017-06, Vol.100 (6), p.e1700101-n/a
Main Authors: Silverio, Daniel L., Kalkeren, Henri A., Ong, Ta‐Chung, Baudin, Mathieu, Yulikov, Maxim, Veyre, Laurent, Berruyer, Pierrick, Chaudhari, Sachin, Gajan, David, Baudouin, David, Cavaillès, Matthieu, Vuichoud, Basile, Bornet, Aurélien, Jeschke, Gunnar, Bodenhausen, Geoffrey, Lesage, Anne, Emsley, Lyndon, Jannin, Sami, Thieuleux, Chloé, Copéret, Christophe
Format: Article
Language:English
Subjects:
Attenuation
Chemical interactions
Decomposition
Dispersion
Dissolution dynamic nuclear polarization
Hybrid organic‐inorganic materials
Hyperpolarization
Irradiation
Magic angle spinning dynamic nuclear polarization
Mesostructured silica
Nitroxide
NMR
Nuclear magnetic resonance
Nuclear reactions
Polarization
Pores
Porosity
Pyruvic acid
Quenching
Radicals
Resonance
Signal to noise ratio
Silica
Silicon dioxide
Solids
Tuning
Walls
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Summary:Hyperpolarization by dynamic nuclear polarization relies on the microwave irradiation of paramagnetic radicals dispersed in molecular glasses to enhance the nuclear magnetic resonance (NMR) signals of target molecules. However, magnetic or chemical interactions between the radicals and the target molecules can lead to attenuation of the NMR signal through paramagnetic quenching and/or radical decomposition. Here we describe polarizing materials incorporating nitroxide radicals within the walls of the solids to minimize interactions between the radicals and the solute. These materials can hyperpolarize pure pyruvic acid, a particularly important substrate of clinical interest, while nitroxide radicals cannot be used, even when incorporated in the pores of silica, because of reactions between pyruvic acid and the radicals. The properties of these materials can be engineered by tuning the composition of the wall by introducing organic functionalities.
ISSN:0018-019X
1522-2675
DOI:10.1002/hlca.201700101