Loading…
Microwave-assisted synthesis, molecular docking, and biological evaluation of 2-arylidene-2H-furo[2,3-f]chromen-3(7H)-ones as antioxidant and antimicrobial agents
An efficient microwave-assisted method of synthesis of some novel 2-arylidene-2 H -furo[2,3- f ]chromen-3(7 H )-ones 6a–j in excellent yields was described and structural assignment of the products was confirmed on the basis of IR, 1 H NMR, 13 C NMR, MS, and analytical data. The synthesized compound...
Saved in:
Published in: | Medicinal chemistry research 2017-08, Vol.26 (8), p.1735-1746 |
---|---|
Main Authors: | , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
cited_by | cdi_FETCH-LOGICAL-c382t-2719c2beb2ff045f735957a52ffc8cfe709039b547654b6a34d967ccbb90a4db3 |
---|---|
cites | cdi_FETCH-LOGICAL-c382t-2719c2beb2ff045f735957a52ffc8cfe709039b547654b6a34d967ccbb90a4db3 |
container_end_page | 1746 |
container_issue | 8 |
container_start_page | 1735 |
container_title | Medicinal chemistry research |
container_volume | 26 |
creator | Ashok, Dongamanti Rangu, Kavitha Gundu, Srinivas Lakkadi, Arunapriya Tigulla, Parthasarathy |
description | An efficient microwave-assisted method of synthesis of some novel 2-arylidene-2
H
-furo[2,3-
f
]chromen-3(7
H
)-ones
6a–j
in excellent yields was described and structural assignment of the products was confirmed on the basis of IR,
1
H NMR,
13
C NMR, MS, and analytical data. The synthesized compounds were screened for antioxidant activity using 2,2-diphenyl-1-picrylhydrazyl and hydrogen peroxide radicals. The compounds
5d
,
5h
,
6a
,
6e
, and
6j
exhibited better radical scavenging ability. Antimicrobial activity results demonstrated that compounds
5b
,
5e
,
6b
,
6c
, and
6e
showed promising antimicrobial potency. The in silico molecular docking studies were also carried out for the inhibition of cyclooxygenase-II enzyme. These molecular docking results were well complemented to the antioxidant activity studies. |
doi_str_mv | 10.1007/s00044-017-1834-9 |
format | article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_1910612271</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1910612271</sourcerecordid><originalsourceid>FETCH-LOGICAL-c382t-2719c2beb2ff045f735957a52ffc8cfe709039b547654b6a34d967ccbb90a4db3</originalsourceid><addsrcrecordid>eNp1UV1rVDEQvYgFa_UH-BbwRWFjJ1-bzaMUdYVKX-qTSEhyk23q3aQm91b7d_ylzro--CIMzBw458wMZxheMHjDAPR5BwApKTBN2UZIah4Np0wpSTeMw2OcAWeuuHgyPO39FkBokOp0-PUph1Z_uPtIXe-5z3Ek_aHMNxHBiuzrFMMyuUbGGr7lslsRV0bic53qLgc3kXjvpsXNuRZSE-HUtYcpj7FEyrc0La1-4StB09dw0-o-Fipe6e1rWkvsxGEVVP7MI_Y_xge8P1zkM3q7XSxzfzacJDf1-PxvPxs-v393fbGll1cfPl68vaRBbPhMuWYmcB89TwlfS1ooo7RTCMMmpKjBgDBeSb1W0q-dkKNZ6xC8N-Dk6MXZ8PLoe9fq9yX22d7WpRVcaZlhsGYcVyCLHVl4ZO8tJnvX8h6_tgzsIQp7jMJiFPYQhTWo4UdNR27ZxfaP839FvwGw943q</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1910612271</pqid></control><display><type>article</type><title>Microwave-assisted synthesis, molecular docking, and biological evaluation of 2-arylidene-2H-furo[2,3-f]chromen-3(7H)-ones as antioxidant and antimicrobial agents</title><source>Springer Link</source><creator>Ashok, Dongamanti ; Rangu, Kavitha ; Gundu, Srinivas ; Lakkadi, Arunapriya ; Tigulla, Parthasarathy</creator><creatorcontrib>Ashok, Dongamanti ; Rangu, Kavitha ; Gundu, Srinivas ; Lakkadi, Arunapriya ; Tigulla, Parthasarathy</creatorcontrib><description>An efficient microwave-assisted method of synthesis of some novel 2-arylidene-2
H
-furo[2,3-
f
]chromen-3(7
H
)-ones
6a–j
in excellent yields was described and structural assignment of the products was confirmed on the basis of IR,
1
H NMR,
13
C NMR, MS, and analytical data. The synthesized compounds were screened for antioxidant activity using 2,2-diphenyl-1-picrylhydrazyl and hydrogen peroxide radicals. The compounds
5d
,
5h
,
6a
,
6e
, and
6j
exhibited better radical scavenging ability. Antimicrobial activity results demonstrated that compounds
5b
,
5e
,
6b
,
6c
, and
6e
showed promising antimicrobial potency. The in silico molecular docking studies were also carried out for the inhibition of cyclooxygenase-II enzyme. These molecular docking results were well complemented to the antioxidant activity studies.</description><identifier>ISSN: 1054-2523</identifier><identifier>EISSN: 1554-8120</identifier><identifier>DOI: 10.1007/s00044-017-1834-9</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Antiinfectives and antibacterials ; Antimicrobial activity ; Antimicrobial agents ; Antioxidants ; Biochemistry ; Biomedical and Life Sciences ; Biomedicine ; Cell Biology ; Chemical synthesis ; Hydrogen peroxide ; Iridium ; Mathematical analysis ; Molecular docking ; NMR ; Nuclear magnetic resonance ; Original Research ; Pharmacology/Toxicology ; Prostaglandin endoperoxide synthase ; Radicals ; Scavenging</subject><ispartof>Medicinal chemistry research, 2017-08, Vol.26 (8), p.1735-1746</ispartof><rights>Springer Science+Business Media New York 2017</rights><rights>Copyright Springer Science & Business Media 2017</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c382t-2719c2beb2ff045f735957a52ffc8cfe709039b547654b6a34d967ccbb90a4db3</citedby><cites>FETCH-LOGICAL-c382t-2719c2beb2ff045f735957a52ffc8cfe709039b547654b6a34d967ccbb90a4db3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Ashok, Dongamanti</creatorcontrib><creatorcontrib>Rangu, Kavitha</creatorcontrib><creatorcontrib>Gundu, Srinivas</creatorcontrib><creatorcontrib>Lakkadi, Arunapriya</creatorcontrib><creatorcontrib>Tigulla, Parthasarathy</creatorcontrib><title>Microwave-assisted synthesis, molecular docking, and biological evaluation of 2-arylidene-2H-furo[2,3-f]chromen-3(7H)-ones as antioxidant and antimicrobial agents</title><title>Medicinal chemistry research</title><addtitle>Med Chem Res</addtitle><description>An efficient microwave-assisted method of synthesis of some novel 2-arylidene-2
H
-furo[2,3-
f
]chromen-3(7
H
)-ones
6a–j
in excellent yields was described and structural assignment of the products was confirmed on the basis of IR,
1
H NMR,
13
C NMR, MS, and analytical data. The synthesized compounds were screened for antioxidant activity using 2,2-diphenyl-1-picrylhydrazyl and hydrogen peroxide radicals. The compounds
5d
,
5h
,
6a
,
6e
, and
6j
exhibited better radical scavenging ability. Antimicrobial activity results demonstrated that compounds
5b
,
5e
,
6b
,
6c
, and
6e
showed promising antimicrobial potency. The in silico molecular docking studies were also carried out for the inhibition of cyclooxygenase-II enzyme. These molecular docking results were well complemented to the antioxidant activity studies.</description><subject>Antiinfectives and antibacterials</subject><subject>Antimicrobial activity</subject><subject>Antimicrobial agents</subject><subject>Antioxidants</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cell Biology</subject><subject>Chemical synthesis</subject><subject>Hydrogen peroxide</subject><subject>Iridium</subject><subject>Mathematical analysis</subject><subject>Molecular docking</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Original Research</subject><subject>Pharmacology/Toxicology</subject><subject>Prostaglandin endoperoxide synthase</subject><subject>Radicals</subject><subject>Scavenging</subject><issn>1054-2523</issn><issn>1554-8120</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNp1UV1rVDEQvYgFa_UH-BbwRWFjJ1-bzaMUdYVKX-qTSEhyk23q3aQm91b7d_ylzro--CIMzBw458wMZxheMHjDAPR5BwApKTBN2UZIah4Np0wpSTeMw2OcAWeuuHgyPO39FkBokOp0-PUph1Z_uPtIXe-5z3Ek_aHMNxHBiuzrFMMyuUbGGr7lslsRV0bic53qLgc3kXjvpsXNuRZSE-HUtYcpj7FEyrc0La1-4StB09dw0-o-Fipe6e1rWkvsxGEVVP7MI_Y_xge8P1zkM3q7XSxzfzacJDf1-PxvPxs-v393fbGll1cfPl68vaRBbPhMuWYmcB89TwlfS1ooo7RTCMMmpKjBgDBeSb1W0q-dkKNZ6xC8N-Dk6MXZ8PLoe9fq9yX22d7WpRVcaZlhsGYcVyCLHVl4ZO8tJnvX8h6_tgzsIQp7jMJiFPYQhTWo4UdNR27ZxfaP839FvwGw943q</recordid><startdate>20170801</startdate><enddate>20170801</enddate><creator>Ashok, Dongamanti</creator><creator>Rangu, Kavitha</creator><creator>Gundu, Srinivas</creator><creator>Lakkadi, Arunapriya</creator><creator>Tigulla, Parthasarathy</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>M7Z</scope><scope>P64</scope></search><sort><creationdate>20170801</creationdate><title>Microwave-assisted synthesis, molecular docking, and biological evaluation of 2-arylidene-2H-furo[2,3-f]chromen-3(7H)-ones as antioxidant and antimicrobial agents</title><author>Ashok, Dongamanti ; Rangu, Kavitha ; Gundu, Srinivas ; Lakkadi, Arunapriya ; Tigulla, Parthasarathy</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c382t-2719c2beb2ff045f735957a52ffc8cfe709039b547654b6a34d967ccbb90a4db3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Antiinfectives and antibacterials</topic><topic>Antimicrobial activity</topic><topic>Antimicrobial agents</topic><topic>Antioxidants</topic><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cell Biology</topic><topic>Chemical synthesis</topic><topic>Hydrogen peroxide</topic><topic>Iridium</topic><topic>Mathematical analysis</topic><topic>Molecular docking</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Original Research</topic><topic>Pharmacology/Toxicology</topic><topic>Prostaglandin endoperoxide synthase</topic><topic>Radicals</topic><topic>Scavenging</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ashok, Dongamanti</creatorcontrib><creatorcontrib>Rangu, Kavitha</creatorcontrib><creatorcontrib>Gundu, Srinivas</creatorcontrib><creatorcontrib>Lakkadi, Arunapriya</creatorcontrib><creatorcontrib>Tigulla, Parthasarathy</creatorcontrib><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biochemistry Abstracts 1</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Medicinal chemistry research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ashok, Dongamanti</au><au>Rangu, Kavitha</au><au>Gundu, Srinivas</au><au>Lakkadi, Arunapriya</au><au>Tigulla, Parthasarathy</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Microwave-assisted synthesis, molecular docking, and biological evaluation of 2-arylidene-2H-furo[2,3-f]chromen-3(7H)-ones as antioxidant and antimicrobial agents</atitle><jtitle>Medicinal chemistry research</jtitle><stitle>Med Chem Res</stitle><date>2017-08-01</date><risdate>2017</risdate><volume>26</volume><issue>8</issue><spage>1735</spage><epage>1746</epage><pages>1735-1746</pages><issn>1054-2523</issn><eissn>1554-8120</eissn><abstract>An efficient microwave-assisted method of synthesis of some novel 2-arylidene-2
H
-furo[2,3-
f
]chromen-3(7
H
)-ones
6a–j
in excellent yields was described and structural assignment of the products was confirmed on the basis of IR,
1
H NMR,
13
C NMR, MS, and analytical data. The synthesized compounds were screened for antioxidant activity using 2,2-diphenyl-1-picrylhydrazyl and hydrogen peroxide radicals. The compounds
5d
,
5h
,
6a
,
6e
, and
6j
exhibited better radical scavenging ability. Antimicrobial activity results demonstrated that compounds
5b
,
5e
,
6b
,
6c
, and
6e
showed promising antimicrobial potency. The in silico molecular docking studies were also carried out for the inhibition of cyclooxygenase-II enzyme. These molecular docking results were well complemented to the antioxidant activity studies.</abstract><cop>New York</cop><pub>Springer US</pub><doi>10.1007/s00044-017-1834-9</doi><tpages>12</tpages></addata></record> |
fulltext | fulltext |
identifier | ISSN: 1054-2523 |
ispartof | Medicinal chemistry research, 2017-08, Vol.26 (8), p.1735-1746 |
issn | 1054-2523 1554-8120 |
language | eng |
recordid | cdi_proquest_journals_1910612271 |
source | Springer Link |
subjects | Antiinfectives and antibacterials Antimicrobial activity Antimicrobial agents Antioxidants Biochemistry Biomedical and Life Sciences Biomedicine Cell Biology Chemical synthesis Hydrogen peroxide Iridium Mathematical analysis Molecular docking NMR Nuclear magnetic resonance Original Research Pharmacology/Toxicology Prostaglandin endoperoxide synthase Radicals Scavenging |
title | Microwave-assisted synthesis, molecular docking, and biological evaluation of 2-arylidene-2H-furo[2,3-f]chromen-3(7H)-ones as antioxidant and antimicrobial agents |
url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-07T21%3A38%3A29IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Microwave-assisted%20synthesis,%20molecular%20docking,%20and%20biological%20evaluation%20of%202-arylidene-2H-furo%5B2,3-f%5Dchromen-3(7H)-ones%20as%20antioxidant%20and%20antimicrobial%20agents&rft.jtitle=Medicinal%20chemistry%20research&rft.au=Ashok,%20Dongamanti&rft.date=2017-08-01&rft.volume=26&rft.issue=8&rft.spage=1735&rft.epage=1746&rft.pages=1735-1746&rft.issn=1054-2523&rft.eissn=1554-8120&rft_id=info:doi/10.1007/s00044-017-1834-9&rft_dat=%3Cproquest_cross%3E1910612271%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c382t-2719c2beb2ff045f735957a52ffc8cfe709039b547654b6a34d967ccbb90a4db3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1910612271&rft_id=info:pmid/&rfr_iscdi=true |