Loading…

Synthesis and morphological insight of new biocompatible smart hydrogels

We present a first report for developing stimulus responsive hydrogels via free radical aqueous polymerization technique using Acrylic acid (AAc), methacrylic acid (MAAc) and diethylaminoethyl methacrylate (DEAEMA). The morphological aspects of poly(AAc-co-DEAEMA) (pAcD) and poly(MAAc-co-DEAEMA) (pM...

Full description

Saved in:
Bibliographic Details
Published in:Journal of polymer research 2017-07, Vol.24 (7), p.1, Article 113
Main Authors: Shakeel, Adeeba, Singh, Aarti, Das, Souvik, Suhag, Deepa, Sharma, Arun Kumar, Rajput, Satyendra Kumar, Mukherjee, Monalisa
Format: Article
Language:English
Subjects:
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We present a first report for developing stimulus responsive hydrogels via free radical aqueous polymerization technique using Acrylic acid (AAc), methacrylic acid (MAAc) and diethylaminoethyl methacrylate (DEAEMA). The morphological aspects of poly(AAc-co-DEAEMA) (pAcD) and poly(MAAc-co-DEAEMA) (pMcD) were investigated to delineate the relevant mechanism of hydrogel formation for better understanding of their mechanical behaviour. The formulated hydrogels were found to have a structural framework comprising inter-connected nanogels and continuous outer skin with macroporous interiors. An abrupt increase in the peak intensities specific to the polymer and a simultaneous decrease in the water related peaks in the attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectra exhibited the phenomenon of phase separation, whereas peaks of proton nuclear magnetic resonance ( 1 HNMR) revealed hydrogen bonding and electrolytic complexation between the monomers. Biocompatibility is the hallmark for any drug carrier and was evaluated by both in vitro and in vivo testing. Administration of the prepared hydrogels to rat models did not cause any significant affect on the vital organs. Graphical abstract Graphical representation showing macroporous interior with interlocked nanoglobules as stable building blocks in pAcD gels with high in-vitro and in-vivo biocompatibility
ISSN:1022-9760
1572-8935
DOI:10.1007/s10965-017-1267-7