Comparative Efficacy and Safety Study of a Newly Developed Moxidectin Containing Formulation (Drench) in Sheep

In the present study, several clinical field trials were conducted to evaluate the efficacy and safety of moxidectin oral drench for sheep. Trial III was a comparable efficacy of Rivermec (R) LV drench for sheep and Cydectin LV (reference product) containing 0.2% moxidectin oral drench formulation w...

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Bibliographic Details
Published in:Journal of pharmaceutical sciences and research 2017-05, Vol.9 (5), p.672
Main Authors: Hossain, M D Kamal, Nahar, Kamrun, Mazumder, Mohammed Ehsanul Hoque, Gestier, Tim, Wahiduzzaman, Md, Alqahtani, Ali S, Gestier, Tony, Hamid, Kaiser
Format: Article
Language:English
Subjects:
Cattle
Humidity
Infections
Parasites
Parasitology
Sheep
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Summary:In the present study, several clinical field trials were conducted to evaluate the efficacy and safety of moxidectin oral drench for sheep. Trial III was a comparable efficacy of Rivermec (R) LV drench for sheep and Cydectin LV (reference product) containing 0.2% moxidectin oral drench formulation was evaluated in summer season (December 2013). Treatment of sheep with 0.2, 0.4, 1.0 mg/kg BW (1X, 2X and 5X levels) of Rivermec (R) LV Drench for Sheep did not cause clinical signs of toxicity in any of the test animals. Gastrointestinal nematodes are the most common parasite in sheep production areas [1] and the use of strategic anthelmintic treatments has become a routine management activity of flocks. [...]the continuous use of a particular chemical product generally results in the appearance of resistant strains [3] which require the use of an alternative anthelmintic with a different mode of action to keep the parasite population under control. The efficacy, safety and withholding period for meat/egg/milk consumption of an antiparasitic compound is related not only to the dose rate but also to its formulation and route of administration [11]. The purpose of this study was to evaluate the efficacy and safety of moxidectin oral drench (Rivermec (R) LV Drench , a new formulation developed by Vetafarm Pty Ltd, Australia) against naturally infected nematodes and establish comparable efficacy of Rivermec (R) LV drench for sheep with the reference product Cydectin® LV ( Virbac, Australia). Two commercial sheep farms were used for the study which were small...
ISSN:0975-1459