Simple Metal‐Free Direct Reductive Amination Using Hydrosilatrane to Form Secondary and Tertiary Amines

This work describes the use of cheap, safe, and easy‐to‐handle hydrosilatrane as the reductant in direct reductive amination reactions. This efficient method enables a facile, metal‐free access to secondary and tertiary amines from a wide range of aldehydes and ketones, with the synthesis of tertiar...

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Bibliographic Details
Published in:Advanced synthesis & catalysis 2017-06, Vol.359 (11), p.1872-1878
Main Authors: Varjosaari, Sami E., Skrypai, Vladislav, Suating, Paolo, Hurley, Joseph J. M., Lio, Ashley M. De, Gilbert, Thomas M., Adler, Marc J.
Format: Article
Language:English
Subjects:
1-hydrosilatrane
Additives
Aldehydes
Amines
Chemical industry
Chemical synthesis
Direct reduction
direct reductive amination
green chemistry
Ketones
metal-free conditions
solvent-free reaction
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Summary:This work describes the use of cheap, safe, and easy‐to‐handle hydrosilatrane as the reductant in direct reductive amination reactions. This efficient method enables a facile, metal‐free access to secondary and tertiary amines from a wide range of aldehydes and ketones, with the synthesis of tertiary amines requiring no additives at all. This reaction demonstrates excellent functional group tolerance, chemoselectivity, and scalability.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.201700079