Progressive nature of obesity and diabetes in nonhuman primates

(5) in this issue as metabolically healthy obesity, progressively move from this relatively healthy state ("insulin sensitive") (6) through metabolic syndrome (including dyslipidemia, hypertension, and other associated comorbidities) to insulin-resistant obesity and overt diabetes (complet...

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Bibliographic Details
Published in:Obesity (Silver Spring, Md.) Md.), 2017-04, Vol.25 (4), p.663-664
Main Author: Hansen, Barbara C.
Format: Article
Language:English
Subjects:
Diabetes
Diet
Insulin resistance
Metabolic syndrome
Obesity
Primates
Online Access:Get full text
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Summary:(5) in this issue as metabolically healthy obesity, progressively move from this relatively healthy state ("insulin sensitive") (6) through metabolic syndrome (including dyslipidemia, hypertension, and other associated comorbidities) to insulin-resistant obesity and overt diabetes (complete with all of the complications known to humans, if studied long enough during insulin-treated advanced diabetes) (6). The most important feature to note is that it is a progressive process (7), as shown in Figure 1, and that this process or progression begins to be observed in individuals at varying ages. [...]the penultimate diagnosis of T2DM in rhesus can be made in some animals as early as age 8 in adult rhesus, and its diagnosis, established during longitudinal careful observation, can show onset as late as age 29 (and perhaps later). [...]we have relied upon "phases" in this progression from normal (phase 1 to severe diabetes [phase 9], as shown in Figure 1). [...]with constant...
ISSN:1930-7381
1930-739X
DOI:10.1002/oby.21818