On the Road to Development of an in Vitro Permeation Test (IVPT) Model to Compare Heat Effects on Transdermal Delivery Systems: Exploratory Studies with Nicotine and Fentanyl

Purpose At elevated temperatures, the rate of drug release and skin permeation from transdermal delivery systems (TDS) may be higher than at a normal skin temperature. The aim of this study was to compare the effect of heat on the transdermal delivery of two model drugs, nicotine and fentanyl, from...

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Bibliographic Details
Published in:Pharmaceutical research 2017-09, Vol.34 (9), p.1817-1830
Main Authors: Shin, Soo Hyeon, Ghosh, Priyanka, Newman, Bryan, Hammell, Dana C., Raney, Sam G., Hassan, Hazem E., Stinchcomb, Audra L.
Format: Article
Language:English
Subjects:
Administration, Cutaneous
Analgesics, Opioid - administration & dosage
Analgesics, Opioid - pharmacokinetics
Analysis
Animal experimentation
Animals
Biochemistry
Biomedical and Life Sciences
Biomedical Engineering and Bioengineering
Biomedicine
Central nervous system depressants
Dermatologic agents
Dermatology
Drug Compounding
Drug delivery
Drug Delivery Systems - instrumentation
Drug Delivery Systems - methods
Exposure
Fentanyl
Fentanyl - administration & dosage
Fentanyl - pharmacokinetics
Formulae, receipts, prescriptions
Formulations
Heat
Heat transfer
Hot Temperature
Medical Law
Nicotine
Nicotine - administration & dosage
Nicotine - pharmacokinetics
Nicotinic Agonists - administration & dosage
Nicotinic Agonists - pharmacokinetics
Permeability
Pharmacology/Toxicology
Pharmacy
Research Paper
Skin
Skin - metabolism
Skin Absorption
Studies
Swine
Temperature effects
Test procedures
Transdermal medication
Transdermal Patch
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Summary:Purpose At elevated temperatures, the rate of drug release and skin permeation from transdermal delivery systems (TDS) may be higher than at a normal skin temperature. The aim of this study was to compare the effect of heat on the transdermal delivery of two model drugs, nicotine and fentanyl, from matrix-type TDSs with different formulations, using in vitro permeation tests (IVPT). Methods IVPT experiments using pig skin were performed on two nicotine and three fentanyl TDSs. Both continuous and transient heat exposures were investigated by applying heat either for the maximum recommended TDS wear duration or for short duration. Results Continuous heat exposure for the two nicotine TDSs resulted in different effects, showing a prolonged heat effect for one product but not the other. The J max enhancement ratio due to the continuous heat effect was comparable between the two nicotine TDS, but significantly different ( p  
ISSN:0724-8741
1573-904X
DOI:10.1007/s11095-017-2189-0