A34 CLINICAL AND CELLULAR STUDIES IN ALLERGIC DISEASE: Origin, Phenotype And Function Of Human Ige Cells

Rationale Immunoglobulin E (IgE) plays a central role in allergic diseases due to its ability to bind to high-affinity receptors on mast cells and induce degranulation upon allergen crosslinking. GO analysis of IgE DEG demonstrated that IgE cells expressed genes associated with N-glycosylation, the...

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Published in:American journal of respiratory and critical care medicine 2017-01, Vol.195
Main Authors: De Lafaille, M A Curotto, Narayanan, S, Narang, V, Wong, G, Aw, D C W, Chandran, N, Saunders, S, Navin, I, Reibman, J, Poidinger, M, Zolezzi, F
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Flow cytometry
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container_title American journal of respiratory and critical care medicine
container_volume 195
creator De Lafaille, M A Curotto
Narayanan, S
Narang, V
Wong, G
Aw, D C W
Chandran, N
Saunders, S
Navin, I
Reibman, J
Poidinger, M
Zolezzi, F
description Rationale Immunoglobulin E (IgE) plays a central role in allergic diseases due to its ability to bind to high-affinity receptors on mast cells and induce degranulation upon allergen crosslinking. GO analysis of IgE DEG demonstrated that IgE cells expressed genes associated with N-glycosylation, the IRE1-XBP1 endoplasmic reticulum unfolded protein response, and mitochondrial oxidative phosphorylation, all indicative of a plasma cell program.
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source Freely Accessible Science Journals; EZB Electronic Journals Library
subjects Flow cytometry
title A34 CLINICAL AND CELLULAR STUDIES IN ALLERGIC DISEASE: Origin, Phenotype And Function Of Human Ige Cells
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