C25 NON-TUBERCULOUS MYCOBACTERIA: FROM BENCH TO CLINIC: Detection Of Aspiration In Patients With Mycobacterium Avium Complex Pulmonary Infection

Results: 12/12 (100%) of patients with MAC pulmonary infection had blue dye staining of the bronchial mucosa vs. 1/7 (14.3%) of control patients. 6/8 (75%) of patients with suspected MAC infection based on symptoms and radiographic abnormalities, but with negative MAC cultures, had evidence of bronc...

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Bibliographic Details
Published in:American journal of respiratory and critical care medicine 2017-01, Vol.195
Main Authors: Lande, L, Rains, E S, Kwait, R, Peng, W, Falkinham, J O, Williams, M, Giger, O, Peterson, D, Greenspon, L, Sawicki, J
Format: Article
Language:English
Subjects:
Biopsy
Infections
Medical imaging
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Summary:Results: 12/12 (100%) of patients with MAC pulmonary infection had blue dye staining of the bronchial mucosa vs. 1/7 (14.3%) of control patients. 6/8 (75%) of patients with suspected MAC infection based on symptoms and radiographic abnormalities, but with negative MAC cultures, had evidence of bronchial mucosal blue dye staining. 8/11 (73%) of patients with detectable bile acids, trypsin or pepsin in the BAL fluid also had evidence of blue dye staining of their airways. Conclusions: 100% of patients with pulmonary MAC infection had evidence of aspiration into the lower respiratory tract. 22% of patients had evidence of MAC in the stomach, likely an underestimate, as gastric aspirate cultures require decontamination measures to reduce numbers of faster growing bacteria.
ISSN:1073-449X
1535-4970