Influence of xanthotoxin (8-methoxypsoralen) on the anticonvulsant activity of various novel antiepileptic drugs against maximal electroshock-induced seizures in mice

The aim of this study was to determine the effects of xanthotoxin (8-methoxypsoralen) on the protective action of 5 various second- and third-generation antiepileptic drugs (i.e., lacosamide, lamotrigine, oxcarbazepine, pregabalin and topiramate) in the mouse maximal electroshock-induced seizure mod...

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Bibliographic Details
Published in:Fitoterapia 2016-12, Vol.115, p.86-91
Main Authors: Zagaja, Mirosław, Andres-Mach, Marta, Patrzylas, Paweł, Pyrka, Daniel, Szpringer, Monika, Florek-Łuszczki, Magdalena, Żółkowska, Dorota, Skalicka-Woźniak, Krystyna, Łuszczki, Jarogniew J.
Format: Article
Language:English
Subjects:
Acetamides
adults
adverse effects
albino
Animals
Anticonvulsants
Anticonvulsants - pharmacology
Antiepileptic agents
Brain
Carbamazepine - analogs & derivatives
Clinical outcomes
Coumarins
Drug delivery systems
Drug Synergism
Drugs
electricity
electrodes
Electroshock - adverse effects
Fructose - analogs & derivatives
Lamotrigine
Male
males
Maximal electroshock-induced seizure test
medicinal plants
methoxsalen
Methoxsalen - pharmacology
Mice
Motor task performance
Muscle strength
Novel antiepileptic drugs
Oxcarbazepine
Pharmacodynamic interaction
Pharmacodynamics
Pharmacology
Pregabalin
Rodents
Seizing
Seizures
Seizures - drug therapy
Side effects
Topiramate
Triazines
Xanthotoxin
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