Design and characterization of PDO biodegradable intravascular stents

Two novel biodegradable intravascular stents (BIS) with different structures are introduced. Braiding-structural BIS and Z-structural BIS were fabricated from polydioxanone (PDO) monofilament by a hand-braiding method with a perforated mold, imitating commercial stents that have been used clinically...

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Bibliographic Details
Published in:Textile research journal 2017-10, Vol.87 (16), p.1968-1976
Main Authors: Wang, Cong-er, Zhang, Pei-hua
Format: Article
Language:English
Subjects:
Biocompatibility
Biodegradability
Biodegradation
Biomedical materials
Braiding
Degradation
Design
Fabrication
Implants
International standards
Materials research
Mechanical properties
Polymers
Porosity
Stents
Surgical implants
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Summary:Two novel biodegradable intravascular stents (BIS) with different structures are introduced. Braiding-structural BIS and Z-structural BIS were fabricated from polydioxanone (PDO) monofilament by a hand-braiding method with a perforated mold, imitating commercial stents that have been used clinically. The fabrication process of these two BIS is described and stent parameters, mechanical properties, and degradation properties are reported. The findings reveal that Z-structural BIS have higher porosity, smaller longitudinal shortening rate, and higher radial force and recovery rate compared with the braiding-structural stent. During the degradation process, braiding-structural BIS maintained their mechanical properties higher than international standards for 12 weeks, while Z-structural stents maintained them for 16 weeks.
ISSN:0040-5175
1746-7748
DOI:10.1177/0040517516660893