A novel and efficient synthesis of 3-iodo substituted 1,8-naphthyridines by electrophilic cyclization of 2-amino nicotinaldehyde and their antimicrobial activity

Synthesis of substituted 1,8-naphthyridines based on 2-aminonicotinaldehyde under mild conditions is studied. Out of three electrophilic iodine sources (I 2 , NIS, and ICl) studied, I 2 was determined to act most efficiently in the process. High overall yields were achieved for aliphatic substitutio...

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Bibliographic Details
Published in:Russian journal of general chemistry 2017-08, Vol.87 (8), p.1794-1799
Main Authors: Sakram, B., Ashok, K., Rambabu, S., Sonyanaik, B., Ravi, D.
Format: Article
Language:English
Subjects:
Aliphatic compounds
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
E coli
Fungi
Fusarium
Fusarium oxysporum
Iodine
Klebsiella
Synthesis
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Summary:Synthesis of substituted 1,8-naphthyridines based on 2-aminonicotinaldehyde under mild conditions is studied. Out of three electrophilic iodine sources (I 2 , NIS, and ICl) studied, I 2 was determined to act most efficiently in the process. High overall yields were achieved for aliphatic substitution at the reaction center. All compounds were evaluated for antibacterial activity ( Staphylococus aureus, Bacillus subtilis, Escherichia coli , and Klebsiella pneumonia ) and anti-fungi activity ( Aspergillus flavus and Fusarium oxysporum ).
ISSN:1070-3632
1608-3350
DOI:10.1134/S1070363217080266