Development and Validation for the Simultaneous Estimation of Lamivudine, Tenofovir Disproxil and Dolutegravir In Drug Product by RP-HPLC

Materials and methods 2.1 Equipments: The chromatographic technique performed on a waters 2695 with 2487 detector and Empower2 software, reversed phase C8 column (Luna C8 150·4.6,3g) as stationary phase ,Ultrasonic cleaner, Scaletech analytical balance ,Vaccum micro filtration unit with 0.45g membra...

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Bibliographic Details
Published in:Journal of pharmaceutical sciences and research 2017-09, Vol.9 (9), p.1505
Main Authors: Nekkala, Kalpana, Kumar, V Shanmukha, Ramachandran, D
Format: Article
Language:English
Subjects:
Acquired immune deficiency syndrome
AIDS
Antiretroviral drugs
HIV
Human immunodeficiency virus
Pharmaceuticals
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Summary:Materials and methods 2.1 Equipments: The chromatographic technique performed on a waters 2695 with 2487 detector and Empower2 software, reversed phase C8 column (Luna C8 150·4.6,3g) as stationary phase ,Ultrasonic cleaner, Scaletech analytical balance ,Vaccum micro filtration unit with 0.45g membrane filter was used in the study. 2.2 Materials: Pharmaceutically pure sample of Lamivudine/Tenofovir DF/Dolutegravir were obtained as gift samples from Fortune pharma training institute, Sri Sai nagar colony, KPHB, Hyderabad, India. [3] http://www.ich.org/ [4] https://www.drugbank.ca/drugs/DB08930 [5] https://www.drugbank.ca/drugs/DB00709 [6] https://www.drugbank.ca/drugs/DB08930 [7] Development and Validation of Analytical Method for Determination of Dolutegravir Sodium, Lamivudine and Tenofovir Disoproxil Fumarate Using Reverse Phase High Performance Liquid Chromatography Author(s): Talari Kalpana, Dr. Tiruveedula Raja Rajeswari, Ramana Reddy Ganji [8] Development and validation of stability-indicating HPLC method for simultaneous determination of Lamivudine, Tenofovir, and Dolutegravir in bulk and their tablet dosage form .Nagasarapu MallikarjunaRaoa. [9] Stability Indicating Gradient RP-HPLC Method for the Simultaneous Estimation of Lamivudine, Abacavir and Dolutegravir in Bulk and their Combined Dosage Form P. Saidulu·,Sk.Mastanamma [10] Simultaneous Estimation of Tenofovir DF and Lamivudine in Synthetic Mixture by RP-HPLC Method Kena H. Patel1 , Shailesh V. Luhar2 , Sachin B. Narkhede3 [11] Development & Validation of HPLC Method for Analysis of Some Antihypertensive Agents in their Pharmaceutical Dosage Forms Shalini pachauria , Sarvesh paliwalb , Kona.S.Srinivasa , Yogendra Singha , Varun Jain [12] DEVELOPMENT OF ASSAY METHOD AND FORCED DEGRADATION STUDY OF LAMIVUDINE AND TENOFOVIR DF BY RP-HPLC IN TABLET FORMULATIONS. Diwan [14] Development and Validation of HPLC Method for Simultaneous Determination of Amlodipine, Lamivudine, Hydrochlorothiazide in Dosage Form and Spiked Human Plasma Samya M. El-Gizawy1 , Osama H. Abdelmageed2 , Mahmoud A. Omar3 , Sayed M. Deryea3 , Ahmed M. Abdel-Megied4 [15] New Method Development and Validation for the Simultaneous Estimation of Tenofovir DF and Lamivudine in A bulk and Pharmaceutical Dosage Forms Swathi Vaka [16] http://www.irjponline.com/admin/php/uploads/1029_pdf.pdf [17] http://www.ncbi.nlm.nih.gov/pubmed/20502563
ISSN:0975-1459