Insilico Study of Thymoquinone as Peroxisome Proliferator Activated Receptor Gamma Agonist in the Treatment of Type 2 Diabetes Mellitus

According to Siswandono and Soekardjo [14], an amino acid which is about 4 - 6A will form van der Waals interactions. A number of hydrogen bonds formed in the ligand-receptor interaction depends on the presence of atomic H, O, N or S ligands which are located around the H atom acts as a hydrogen bon...

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Bibliographic Details
Published in:Journal of pharmaceutical sciences and research 2017-09, Vol.9 (9), p.1478
Main Authors: Megantara, Sandra, Utami, Dwi, Puspitasari, Lia, Mustarichie, Resmi
Format: Article
Language:English
Subjects:
Biological activity
Breast cancer
Chemical bonds
Diabetes
Ligands
Natural products
Proteins
Software
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Summary:According to Siswandono and Soekardjo [14], an amino acid which is about 4 - 6A will form van der Waals interactions. A number of hydrogen bonds formed in the ligand-receptor interaction depends on the presence of atomic H, O, N or S ligands which are located around the H atom acts as a hydrogen bond donor, while O atoms, N, and S acts as a hydrogen bond acceptor. According to Bohm and Schneider [15], the range of hydrogen bond distances are good docking simulation results are 1.72-2.85 Å. The four compounds had bond distances in the range, in other words, that the four compounds had a hydrogen bond distance corresponding requirements so that they could interact with either the tyrosinase enzyme through hydrogen bonding. According to Siswandono and Soekardjo [14,16], amino acids that are about 4-6A will form van der Waals interactions.
ISSN:0975-1459