Expression of BC1 Impairs Spatial Learning and Memory in Alzheimer’s Disease Via APP Translation

Aggregation of amyloid-β (Aβ) peptides, which are the cleavage products of amyloid precursor protein (APP), is a major pathological hallmark in the brain of Alzheimer’s disease (AD). Now, we know little about the roles of APP translation in the disease progression of AD. Here, we show that BC1, a lo...

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Bibliographic Details
Published in:	Molecular neurobiology 2018-07, Vol.55 (7), p.6007-6020
Main Authors:	Zhang, Tongmei, Pang, Pei, Fang, Zemin, Guo, Yu, Li, Hao, Li, Xinyan, Tian, Tian, Yang, Xin, Chen, Wenting, Shu, Shu, Tang, Na, Wu, Jianhua, Zhu, Houze, Pei, Lei, Liu, Dan, Tian, Qing, Wang, Jian, Wang, Lin, Zhu, Ling-Qiang, Lu, Youming
Format:	Article
Language:	English
Subjects:	Alzheimer Disease - genetics Alzheimer Disease - physiopathology Alzheimer's disease Amyloid beta-Protein Precursor - genetics Amyloid beta-Protein Precursor - metabolism Amyloid precursor protein Animal memory Animals Biomedical and Life Sciences Biomedicine Cell Biology Fragile X Mental Retardation Protein - metabolism Fragile X syndrome Intellectual disabilities Learning Memory Memory Disorders - genetics Memory Disorders - physiopathology Mice, Inbred C57BL Mice, Transgenic mRNA Neurobiology Neurodegenerative diseases Neurology Neurosciences Peptides Protein Biosynthesis Pyramidal cells RNA, Long Noncoding - genetics RNA, Long Noncoding - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism Rodents Spatial discrimination Spatial discrimination learning Spatial Learning Spatial memory Translation
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