Supplementation of Cerelac baby food with yeast–probiotic cocktail strains induces high potential for aflatoxin detoxification both in vitro and in vivo in mother and baby albino rats

BACKGROUND Aflatoxins (AFs) are a group of toxic, nephrotoxic, hepatotoxic and carcinogenic fungal metabolites. Heat‐ and acid‐treated yeasts, probiotic bacteria and their combination were used to remove AFB1, AFB2, AFG1 and AFG2 from human and animal food. RESULTS The in vitro study revealed that t...

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Bibliographic Details
Published in:Journal of the science of food and agriculture 2018-01, Vol.98 (2), p.707-718
Main Authors: Hamad, Gamal M, Taha, Tarek H, Hafez, Elsayed E, Ali, Safwat H, El Sohaimy, Sobhy A
Format: Article
Language:English
Subjects:
Aflatoxins
Aflatoxins - toxicity
Animal health
Animals
Babies
Baby foods
Bacteria
Biocompatibility
Carcinogens
Detoxification
detoxification and yeast–probiotic cocktail
Dietary supplements
Female
Food Contamination
Humans
in vitro and in vivo
Infant
Infant Food
Infants
Metabolites
Microscopy, Electron, Scanning
Phosphates
probiotic bacteria
Probiotics
Probiotics - administration & dosage
Probiotics - pharmacology
Random Allocation
Rats
Rats, Sprague-Dawley
Saccharomyces cerevisiae
Yeast
Yeasts
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Summary:BACKGROUND Aflatoxins (AFs) are a group of toxic, nephrotoxic, hepatotoxic and carcinogenic fungal metabolites. Heat‐ and acid‐treated yeasts, probiotic bacteria and their combination were used to remove AFB1, AFB2, AFG1 and AFG2 from human and animal food. RESULTS The in vitro study revealed that the highest removal percentage of AFs in phosphate‐buffered saline was recorded after 72 h with the yeast–probiotic coctile, reaching 95.59%. Therefore, this coctile was added to Cerelac contaminated with AFB1, AFB2, AFG1 and AFG2, and the removal percentages were 8.17%, 36.12%, 44.75%, 64.72% and 93.21% after 6, 12, 24, 48 and 72 h of treatment, respectively. Cerelac yeast–probiotic coctile was administered to female rats and the results showed that all AFs (AFB1, AFB2, AFG1 and AFG2) were detected in the serum of mother rats for both AF groups III and IV. On the other hand, AFM1 and AFM2 metabolites were not observed in mothers' sera but were detected in all infants of groups III and IV. Meanwhile, AFB1, AFB2, AFG1 and AFG2 were not observed in infants' sera. CONCLUSION A mixture of yeast–probiotic coctile was successful in reducing the level of AF in rat sera and diminished the deleterious effect of AFs on animal health. © 2017 Society of Chemical Industry
ISSN:0022-5142
1097-0010
DOI:10.1002/jsfa.8518