Low-level laser therapy can reduce lipopolysaccharide-induced contractile force dysfunction and TNF-[alpha] levels in rat diaphragm muscle

Our objective was to investigate if low-level laser therapy (LLLT) could improve respiratory function and inhibit tumor necrosis factor (TNF-alpha) release into the diaphragm muscle of rats after an intravenous injection of lipopolysaccharide (LPS) (5 mg/kg). We randomly divided Wistar rats in a con...

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Bibliographic Details
Published in:Lasers in medical science 2006-12, Vol.21 (4), p.238
Main Author: F. AimbireR. A. B. Lopes-MartinsH. C. Castro-Faria-NetoR. AlbertiniM. C. ChavantesM. T. T. PachecoP. S. L. M. LeonardoV. V. IversenJ. M. Bjordal
Format: Article
Language:English
Subjects:
Gangrene
Lasers
Medical treatment
Muscular system
Rodents
Tumors
Online Access:Get full text
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Summary:Our objective was to investigate if low-level laser therapy (LLLT) could improve respiratory function and inhibit tumor necrosis factor (TNF-alpha) release into the diaphragm muscle of rats after an intravenous injection of lipopolysaccharide (LPS) (5 mg/kg). We randomly divided Wistar rats in a control group without LPS injection, and LPS groups receiving either (a) no therapy, (b) four sessions in 24 h with diode Ga-AsI-Al laser of 650 nm and a total dose of 5.2 J/cm2, or (c) an intravenous injection (1.25 mg/kg) of the TNF-alpha inhibitor chlorpromazine (CPZ). LPS injection reduced maximal force by electrical stimulation of diaphragm muscle from 24.15+/-0.87 N in controls, but the addition of LLLT partly inhibited this reduction (LPS only: 15.01+/-1.1 N vs LPS+LLLT: 18.84+/-0.73 N, P
ISSN:0268-8921
1435-604X
DOI:10.1007/s10103-006-0405-y