A Review of Safety and Hazards Associated With the Artificial Pancreas

The artificial pancreas (AP) is a closed-loop device with the potential to reduce the complications associated with type 1 diabetes mellitus by maintaining euglycemia in patients. The AP encompasses an algorithm that determines the amount of insulin (and other hormones) to be administered to the pat...

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Bibliographic Details
Published in:IEEE reviews in biomedical engineering 2017, Vol.10, p.44-62
Main Authors: Ramkissoon, Charrise M., Aufderheide, Brian, Bequette, B. Wayne, Vehi, Josep
Format: Article
Language:English
Subjects:
Artificial pancreas (AP)
Biomedical measurement
Biomedical monitoring
Blood Glucose Self-Monitoring
Commercialization
Complications
Diabetes
Diabetes mellitus
faults
Glucagon - administration & dosage
Glucose
Guidelines as Topic
Hazards
Hormones
Humans
Injections, Subcutaneous
Insulin
Insulin Infusion Systems
Pancreas
Pancreas, Artificial - adverse effects
Patient monitoring
Safety
type 1 diabetes
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Summary:The artificial pancreas (AP) is a closed-loop device with the potential to reduce the complications associated with type 1 diabetes mellitus by maintaining euglycemia in patients. The AP encompasses an algorithm that determines the amount of insulin (and other hormones) to be administered to the patient via a continuous subcutaneous insulin infusion pump using information provided by a continuous glucose monitor and other sensors. As the AP approaches commercialization, special attention must be given to safety within all the individual components, including physiological changes in the patient, as well as safety issues that can arise when these components are combined into a single system. Therefore, we analyzed the specific hazards applicable to the AP with the aim of exposing areas of safety that are yet to be addressed.
ISSN:1937-3333
1941-1189
DOI:10.1109/RBME.2017.2749038