Optimal Tolerance Design and Optimization for a Pharmaceutical Quality Characteristic

A number of pharmaceutical quality characteristics are destructive or too costly to inspect. However, most quality improvement tools developed in the pharmaceutical research community typically assume that quality characteristics are nondestructive. This paper proposes a new design system for qualit...

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Bibliographic Details
Published in:Mathematical problems in engineering 2013-01, Vol.2013 (2013), p.1-17
Main Authors: Shin, Sangmun, Truong, Nguyen Khoa Viet, Kongsuwan, Pauline, Jeong, Seong Hoon
Format: Article
Language:English
Subjects:
Automation
Design optimization
Engineering
Mathematical problems
Multivariate analysis
Pharmaceutical sciences
Pharmaceuticals
Product quality
Random variables
Researchers
Robust design
Sensitivity analysis
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Summary:A number of pharmaceutical quality characteristics are destructive or too costly to inspect. However, most quality improvement tools developed in the pharmaceutical research community typically assume that quality characteristics are nondestructive. This paper proposes a new design system for quality improvement by incorporating the concept of surrogate variables with the concepts of robust design (RD) and tolerance design (TD). The proposed robust-tolerance design paradigm determines the optimal factor setting and specification limits simultaneously, thereby improving quality of pharmaceutical products. In addition, the proposed methodology can provide the optimal tolerance as a mathematical closed-form solution. Finally, a numerical example and its associated sensitivity analysis for a pharmaceutical case are conducted for verification purposes. Based on the numerical example results, the proposed approach could provide robust factor settings with significant tradeoffs between quality and cost.
ISSN:1024-123X
1563-5147
DOI:10.1155/2013/706962