COPD: more than respiratory/Authors' reply

A paper by Young and colleagues1 suggested that lung volumes, such as reduced forced expiratory volume in 1 s (FEV^sub 1^), can serve as a marker of premature death when assessing baseline risk of chronic obstructive pulmonary disease, lung cancer, coronary artery disease, and stroke, collectively a...

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Bibliographic Details
Published in:The Lancet (British edition) 2008-01, Vol.371 (9606), p.26
Main Authors: Antonelli-Incalzi, Raffaele, Pedone, Claudio, Puhan, M A, Zoller, M, Riet, G ter, Rabe, Klaus F, Fabbri, Leonardo M
Format: Article
Language:English
Subjects:
Cardiovascular disease
Cardiovascular diseases
Chronic obstructive pulmonary disease
Family physicians
Lung cancer
Metabolic disorders
Respiratory diseases
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Summary:A paper by Young and colleagues1 suggested that lung volumes, such as reduced forced expiratory volume in 1 s (FEV^sub 1^), can serve as a marker of premature death when assessing baseline risk of chronic obstructive pulmonary disease, lung cancer, coronary artery disease, and stroke, collectively accounting for 70-80% of premature deaths in smokers. Conceptually we will therefore also have to reconsider the traditional spirometric classifications of severity of COPD, considering not only that it should include the other components of chronic systemic inflammatory syndrome outlined in our Viewpoint, but also that the levels of FEV^sub 1^ might be used for classification of severity of other chronic diseases, particularly cardiovascular disease and metabolic syndrome.2 In identifying factors that constitute the basis of chronic systemic inflammatory syndrome as a diagnosis, we were guided by the available published evidence, and conceded that this list might not be exhaustive and suggested that our syndromic approach be tested prospectively in clinical trials.
ISSN:0140-6736
1474-547X