p53 mutations in lung cancers from non-smoking atomic-bomb survivors

Tobacco smoke contains many carcinogens and has been linked with the development of lung cancer. We sequenced the conserved regions of the p53 tumour suppressor gene in lung cancers from 17 non-smokers from Hiroshima, Japan; 9 were atomic-bomb survivors. The mutations were predominantly transitions...

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Bibliographic Details
Published in:The Lancet (British edition) 1993-12, Vol.342 (8886), p.1520-1521
Main Authors: Takeshima, Y, Bennett, WP, Land, CE, Harris, CC, Inai, K, Takeshima, Y., Seyama, T, Akiyama, M, Tokuoka, S, Mabuchi, K
Format: Article
Language:English
Subjects:
Adult
Aged
Carcinogens
DNA Mutational Analysis
Genes, p53
Humans
Japan
Lung cancer
Lung Neoplasms - genetics
Medical research
Middle Aged
Mutation
Neoplasms, Radiation-Induced - genetics
Nuclear Warfare
Retrospective Studies
Smoking
Tobacco
Tobacco smoke
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Summary:Tobacco smoke contains many carcinogens and has been linked with the development of lung cancer. We sequenced the conserved regions of the p53 tumour suppressor gene in lung cancers from 17 non-smokers from Hiroshima, Japan; 9 were atomic-bomb survivors. The mutations were predominantly transitions (all G:C to A:T); there were no G:C to T:A transversions. By contrast, lung cancers from 77 Japanese smokers have a predominance of G:C to T:A transversions in which the guanine residues occur on the non-transcribed DNA strand. These findings further implicate tobacco smoke carcinogens in the molecular pathogenesis of lung cancer.
ISSN:0140-6736
1474-547X
DOI:10.1016/S0140-6736(05)80087-X