Sodium sensitivity and cardiovascular events in patients with essential hypertension

In patients with sodium-sensitive hypertension, glomerular pressure is increased and microalbuminuria, a marker of glomerular hypertension, is a predictor of cardiovascular events. Similarly, the lack of a nocturnal decrease in blood pressure in these patients is also associated with an increased ri...

Full description

Saved in:
Bibliographic Details
Published in:The Lancet (British edition) 1997-12, Vol.350 (9093), p.1734-1737
Main Authors: Morimoto, Atsushi, Uzu, Takashi, Fujii, Takashi, Nishimura, Masataka, Kuroda, Setsuko, Nakamura, Satoko, Inenaga, Takashi, Kimura, Genjiro
Format: Article
Language:English
Subjects:
Adult
Angina pectoris
Arterial hypertension. Arterial hypotension
Biological and medical sciences
Blood and lymphatic vessels
Blood pressure
Blood Pressure - drug effects
Cardiology. Vascular system
Cardiovascular Diseases - etiology
Clinical manifestations. Epidemiology. Investigative techniques. Etiology
Female
Follow-Up Studies
Health risks
Heart attacks
Humans
Hypertension
Hypertension - complications
Hypertension - physiopathology
Kidney Glomerulus - drug effects
Male
Medical sciences
Middle Aged
Predictive Value of Tests
Prognosis
Proportional Hazards Models
Retrospective Studies
Risk factors
Sodium
Sodium, Dietary - administration & dosage
Sodium, Dietary - adverse effects
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In patients with sodium-sensitive hypertension, glomerular pressure is increased and microalbuminuria, a marker of glomerular hypertension, is a predictor of cardiovascular events. Similarly, the lack of a nocturnal decrease in blood pressure in these patients is also associated with an increased risk of cardiovascular events. We hypothesised that sodium sensitivity may be the common factor and carried out a retrospective study of cardiovascular events in patients with essential hypertension who had had sodium sensitivity measured in our clinic. Sodium sensitivity was assessed in about 350 patients with essential hypertension during the initial investigation of their disorder. The definition of sodium sensitivity was a 10% or greater difference in blood pressure on low-sodium or high-sodium diets. By alphabetical order, the records of 201 patients were obtained and 156 patients without pre-existing disorders were followed up. The records of patients who had a cardiovascular event or died were reviewed without knowledge of the patient's sodium-sensitivity status. 62 patients were deemed sodium sensitive and 94 non-sodium sensitive. Left-ventricular hypertrophy was found more frequently in the sodium-sensitive group than in the non-sodium-sensitive group (38 vs 16%; p
ISSN:0140-6736
1474-547X
DOI:10.1016/S0140-6736(97)05189-1