Distribution of IL28B and IL10 polymorphisms as genetic predictors of treatment response in Pakistani HCV genotype 3 patients

There are over 10 million hepatitis C virus (HCV)-infected patients in Pakistan. For these patients, a combination of interferon with ribavirin is the most economical and easily available treatment. Single-nucleotide polymorphisms in interleukin genes have been reported to be associated with the pat...

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Bibliographic Details
Published in:Archives of virology 2018-04, Vol.163 (4), p.997-1008
Main Authors: Naeemi, Humaira, Aslam, Rabia, Raza, Syed Mohsin, Shahzad, Muhammad Aiman, Naz, Shagufta, Manzoor, Sobia, Khaliq, Saba
Format: Article
Language:English
Subjects:
Adult
Alleles
Antiviral Agents - therapeutic use
Biomarkers - metabolism
Biomedical and Life Sciences
Biomedicine
Case-Control Studies
Cytokines
Drug Therapy, Combination
Female
Gene Expression
Gene Frequency
Gene polymorphism
Genotypes
Haplotypes
Hepacivirus - classification
Hepacivirus - drug effects
Hepacivirus - genetics
Hepacivirus - isolation & purification
Hepatitis C
Hepatitis C, Chronic - diagnosis
Hepatitis C, Chronic - drug therapy
Hepatitis C, Chronic - genetics
Hepatitis C, Chronic - immunology
Humans
Infectious Diseases
Interferon
Interferon-alpha - therapeutic use
Interferons
Interleukin 1
Interleukin 10
Interleukin-10 - genetics
Interleukin-10 - immunology
Interleukins - genetics
Interleukins - immunology
Male
Medical Microbiology
Middle Aged
Original Article
Pakistan
Patients
Polyethylene Glycols - therapeutic use
Polymorphism
Polymorphism, Single Nucleotide
Population studies
Prognosis
Recombinant Proteins - therapeutic use
Ribavirin
Ribavirin - therapeutic use
Single-nucleotide polymorphism
Virology
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Summary:There are over 10 million hepatitis C virus (HCV)-infected patients in Pakistan. For these patients, a combination of interferon with ribavirin is the most economical and easily available treatment. Single-nucleotide polymorphisms in interleukin genes have been reported to be associated with the pathogenesis and clearance of HCV, and sustained virologic response (SVR). An interleukin 28B ( IL28B ) gene polymorphism has been shown to modify treatment outcomes, but the effects of interleukin 10 ( IL10 ) polymorphisms have not been previously assessed in the Pakistani population. The present study was conducted with 302 subjects categorized into two groups: 100 healthy volunteers (Group I) and 202 patients with chronic HCV (Group II). Patients within Group II were further divided into two subgroups according to therapeutic response: SVR (responders = 132) and NR (non-responders/relapsers = 70). IL28B (rs8099917, rs12979860) and IL10 (rs1800872, rs1800871, rs1800896) gene polymorphisms were studied in all subjects. A significant difference in the distribution of IL28B rs12979860C/T genotypes between the two groups ( p
ISSN:0304-8608
1432-8798
DOI:10.1007/s00705-018-3711-3