Efficient click reaction towards novel sulfonamide hybrids by molecular hybridization strategy as antiproliferative agents

 Twelve novel sulfonamide hybrids were designed by molecular hybridization strategy. The target sulfonamide hybrids were obtained in the click reaction of azide derivatives and commerciallly available alkynes. All sulfonamide hybrids were evaluated for their antiproliferative activity against three...

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Published in:Journal of chemical sciences (Bangalore, India) India), 2018, Vol.130 (1), p.1-7, Article 6
Main Authors: Fu, Dong-Jun, Hou, Yu-Hui, Zhang, Sai-Yang, Zhang, Yan-Bing
Format: Article
Language:English
Subjects:
Alkynes
Anticancer properties
Antiproliferatives
Biotechnology
Cancer
Chemical reactions
Chemical synthesis
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Hybridization
Lead compounds
Regular Article
Strategy
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Summary: Twelve novel sulfonamide hybrids were designed by molecular hybridization strategy. The target sulfonamide hybrids were obtained in the click reaction of azide derivatives and commerciallly available alkynes. All sulfonamide hybrids were evaluated for their antiproliferative activity against three selected cancer cell lines (MGC-803, EC-109 and PC-3). Most of the synthesized compounds exhibited moderate to good activity against all the cancer cell lines selected. Particularly, compound 8c showed the potent antiproliferative activity with an IC 50 value of 0.7 μ mol against MGC-803 cancer cells. These sulfonamide hybrids might be promising lead compounds to develop antitumor agents in the clinical practice. Graphical Abstract SYNOPSIS. Twelve novel sulfonamide hybrids were designed by molecular hybridization strategy. These sulfonamide hybrids were synthesized by click reaction and evaluated for their antiproliferative activity. Among them, compound 8c showed potent antiproliferative activity with an IC 50 value of 0.7 μ mol against MGC-803 cells.
ISSN:0974-3626
0973-7103
DOI:10.1007/s12039-017-1415-y